mariovitali
Senior Member (Voting Rights)
Dear All,
I wanted to present here my Research that is performed using advanced analytical techniques. Many of you may know me from Phoenix Rising but i wanted to take the opportunity to present this work here as well.
Regarding my background , i am a Data Scientist / Machine Learning Engineer with 18 years of experience. You can see my LinkedIn profile here. I also began making tweets to specific people / organizations on twitter, hoping to turn their attention. My twitter account can be found here
Before continuing, it is important to say that this Research was able to identify key elements of ME/CFS (and possibly other syndromes such as Post-Finasteride Syndrome, Gulf War Illness Syndrome, etc) before any other Researcher.
These elements are the following :
-Pyruvate Dehydrogenase Complex
-Phospholipids Metabolism
-Bile Acids Metabolism
-Possible Liver Involvement
The work (a 32-page document) has been first presented to Professor Ron Davis in October 2017 who got interested after some findings and also to Professors Derya Unutmaz and Maureen Hanson who have found the hypothesis being discussed as very / quite interesting respectively.
I am also in talks with Professor Modra Murovska of the EUROMENE Network so that i may present this work this coming September in London.
In a nutshell : Machine Learning, Network Analysis, Natural Language Processing and Root-cause Analysis techniques were used to identify the most probable biological targets as origins of several syndromes, including ME/CFS. All techniques identify the Liver as the main area of interest.
The original post on Phoenix Rising can be found here :
Here are some latest findings using the techniques discussed :
- Primary target is still Liver function. A "Liver Stressor" such as a Virus, Medications or even prolonged Stress may disrupt Liver function which in turn disrupts key metabolic pathways that include Bile Acid Metabolism, Endoplasmic Reticulum Stress, Phagocytosis, Vitamin K Metabolism (list not inclusive)
-The importance of Gut, Gut Microbiome and Gut lining is confirmed by these techniques. However we need to ask why we have altered Gut Microbiome and impaired Gut Lining : Could impaired Liver function be responsible for this? An important paper for those looking at the Gut Microbiome can be found here :
https://www.nature.com/articles/s41575-018-0011-z
-The relevance of Sepsis, Lactate are also confirmed.
See below the ranking of Topic importance :
There are also some key questions that are to this day unanswered :
1) What is the prevalence of *any* of the following conditions to ME/CFS Patients ? :
https://bit.ly/2s3YzFy (Note that 3 tabs exist)
2) How many ME/CFS Patients have Liver Fibrosis ? (a test called Fibroscan may be used for this)
3) What is the percentage of ME/CFS having impaired Bile Acids Metabolism? Despite the extensive testing, a very simple test such as Total Bile Acids (TBA) has not been performed on a large scale to ME/CFS patients to this day.
My goal is to have Researchers look more closely to the Liver. In my e-mails to several of them i have stated that the following are readily available for evaluation under strictly controlled conditions where applicable :
1) A Number of SNPs with potentially high relevance to ME/CFS and several other syndromes
2) A Personalised Regimen that may ameliorate or even halt ME/CFS Symptoms
3) A methodology that is able to predict the severity / existence of Symptoms
Ultimately, i am looking to collect a large number of ME/CFS Patients with the Issues listed on the file i linked above and to convince Researchers to look at this Hypothesis.
I further hypothesise that ME/CFS Research has not advanced simply because ME/CFS Researchers have made the false assumption that since Liver Enzymes such as SGOT, SGPT, γ-GT are not elevated, therefore Liver function is not an issue. Unfortunately, the only way to fully assess Liver function is through Liver Biopsy from multiple sites.
Thank you for your attention.
I wanted to present here my Research that is performed using advanced analytical techniques. Many of you may know me from Phoenix Rising but i wanted to take the opportunity to present this work here as well.
Regarding my background , i am a Data Scientist / Machine Learning Engineer with 18 years of experience. You can see my LinkedIn profile here. I also began making tweets to specific people / organizations on twitter, hoping to turn their attention. My twitter account can be found here
Before continuing, it is important to say that this Research was able to identify key elements of ME/CFS (and possibly other syndromes such as Post-Finasteride Syndrome, Gulf War Illness Syndrome, etc) before any other Researcher.
These elements are the following :
-Pyruvate Dehydrogenase Complex
-Phospholipids Metabolism
-Bile Acids Metabolism
-Possible Liver Involvement
The work (a 32-page document) has been first presented to Professor Ron Davis in October 2017 who got interested after some findings and also to Professors Derya Unutmaz and Maureen Hanson who have found the hypothesis being discussed as very / quite interesting respectively.
I am also in talks with Professor Modra Murovska of the EUROMENE Network so that i may present this work this coming September in London.
In a nutshell : Machine Learning, Network Analysis, Natural Language Processing and Root-cause Analysis techniques were used to identify the most probable biological targets as origins of several syndromes, including ME/CFS. All techniques identify the Liver as the main area of interest.
The original post on Phoenix Rising can be found here :
Here are some latest findings using the techniques discussed :
- Primary target is still Liver function. A "Liver Stressor" such as a Virus, Medications or even prolonged Stress may disrupt Liver function which in turn disrupts key metabolic pathways that include Bile Acid Metabolism, Endoplasmic Reticulum Stress, Phagocytosis, Vitamin K Metabolism (list not inclusive)
-The importance of Gut, Gut Microbiome and Gut lining is confirmed by these techniques. However we need to ask why we have altered Gut Microbiome and impaired Gut Lining : Could impaired Liver function be responsible for this? An important paper for those looking at the Gut Microbiome can be found here :
https://www.nature.com/articles/s41575-018-0011-z
-The relevance of Sepsis, Lactate are also confirmed.
See below the ranking of Topic importance :
There are also some key questions that are to this day unanswered :
1) What is the prevalence of *any* of the following conditions to ME/CFS Patients ? :
https://bit.ly/2s3YzFy (Note that 3 tabs exist)
2) How many ME/CFS Patients have Liver Fibrosis ? (a test called Fibroscan may be used for this)
3) What is the percentage of ME/CFS having impaired Bile Acids Metabolism? Despite the extensive testing, a very simple test such as Total Bile Acids (TBA) has not been performed on a large scale to ME/CFS patients to this day.
My goal is to have Researchers look more closely to the Liver. In my e-mails to several of them i have stated that the following are readily available for evaluation under strictly controlled conditions where applicable :
1) A Number of SNPs with potentially high relevance to ME/CFS and several other syndromes
2) A Personalised Regimen that may ameliorate or even halt ME/CFS Symptoms
3) A methodology that is able to predict the severity / existence of Symptoms
Ultimately, i am looking to collect a large number of ME/CFS Patients with the Issues listed on the file i linked above and to convince Researchers to look at this Hypothesis.
I further hypothesise that ME/CFS Research has not advanced simply because ME/CFS Researchers have made the false assumption that since Liver Enzymes such as SGOT, SGPT, γ-GT are not elevated, therefore Liver function is not an issue. Unfortunately, the only way to fully assess Liver function is through Liver Biopsy from multiple sites.
Thank you for your attention.
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