Preprint ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two-Day Cardiopulmonary Exercise Testing, 2026, Davenport+

[Utsikt]

in muscle it certainly would

So what Davenport et al say might be anaerobic metabolic abnormalities in pwME/CFS might still be normal anaerobic metabolism for very inactive people?

 

[DMissa]

So what Davenport et al say might be anaerobic metabolic abnormalities in pwME/CFS might still be normal anaerobic metabolism for very inactive people?

This would depend on whether differences in activity levels between the cohorts are sufficient to elicit an effect on this in muscle.

 

[Eddie]

I wanted to have another look at this paper in light of the recent CPET study that reported no difference.

The point of the 2 day CPET is to show a difference between the Vo2 and workload on day 2 of the test. That decrease is meant to represent the impact of PEM.

However, this paper does not address the change in CPET results between the days at all as far as I can see. The paper focuses on the differences in Vo2 and workload, but not on the differences in the changes between test 1 and 2. I feel like I have to be missing something because that makes the results completely uninteresting... The vast majority of the significant differences between healthy controls and pwME in test 2 were also present in test 1. So all this shows is that the controls were somewhat fitter than pwME, which is not surprising and is just a reflection of poor control selection. I honestly can't understand why they wouldn't have commented on the differences between the responses to the CPETs.

 

[ME/CFS Science Blog]

However, this paper does not address the change in CPET results between the days at all as far as I can see.

Been a while since I read this paper but think this is found in the test by group interaction of their ANOVA modelling.

 

[Eddie]

Been a while since I read this paper but think this is found in the test by group interaction of their ANOVA modelling.

Do you remember which table that is?

Table 2 are the mean results by test at maximal exertion. Table 3 is the average difference between groups (but I don't think it shows the average difference between the tests by group which is what I think matters). Table 4 are the mean results at VAT.

 

[ME/CFS Science Blog]

Do you remember which table that is?

Think it's mentioned in the text, not in a table.