1. Guest, the 'News in Brief' for the week beginning 1st August 2022 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

ME researcher Jonas Bergquist - interviews, talks

Discussion in 'ME/CFS research news' started by Sly Saint, Nov 17, 2020.

  1. Hutan

    Hutan Moderator Staff Member

    Messages:
    20,122
    Location:
    Australia
    janice, cfsandmore, mango and 2 others like this.
  2. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,914
    Post copied from the News from Scandinavia thread.

    OMF has scheduled a YouTube video to premiere on May 3, 2022.

    "Dr. Jonas Bergquist updates on ME/CFS Research Progress! May Momentum Tuesdays 2022

    Jonas Bergquist, MD, PhD, is OMF's Chief Medical Officer & Director of the Uppsala ME/CFS Collaborative Research Center (CRC). Today he shares updates from Uppsala CRC's #LongCOVID research study, findings from the cerebral spinal fluid of ME/CFS patients, and more."

     
    Last edited by a moderator: Apr 28, 2022
    Hutan and MEMarge like this.
  3. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,914
    (Post copied from the News from Scandinavia thread.)

    Jonas Bergquist on Swedish TV earlier this week:

    Ny forskning: Snart kan det finnas ett test som visar om du har ME
    https://www.tv4.se/artikel/6srgEVVz...an-det-finnas-ett-test-som-visar-om-du-har-me
    Post/thread about the segment on Malou Efter Tio's Facebook page.

    ETA: Forum thread about the study:
    https://www.s4me.info/threads/sweden-me-cfs-lactate-glucose-and-hypoxanthine.21615/
     
    oldtimer, MEMarge and Trish like this.
  4. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

    Messages:
    1,098
    Hutan, mango, Trish and 1 other person like this.
  5. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,914
    Hutan, cfsandmore and Trish like this.
  6. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,914
    Trish likes this.
  7. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

    Messages:
    1,098
    “- There are major similarities around fatigue, but one difference we can see is that ME patients typically have no known lasting lung impact, unlike a larger proportion of post-covid patients.”


    That’s because pre-Covid MECFS patients didn’t have acute lung damage from Covid Pneumonia! So if you had Covid and now meet the criteria for MECFS and you have lung damage then you have MECFS plus you have lung damage. I don’t think it’s that complicated.
     
    Last edited by a moderator: May 29, 2022
    Amw66 likes this.
  8. Hutan

    Hutan Moderator Staff Member

    Messages:
    20,122
    Location:
    Australia
    A 28 minute watch. There isn't a lot that is particularly meaty. Here's a summary of the bits I found interesting.

    They have a substantial biobank of longitudinal samples from herpes simplex encephalopathy (HSE) patients - CSF, blood, urine, brain imaging, from infection to 2 years. They are monitoring inflammatory protein markers, cell damage protein markers, metabolites.

    They are looking at auto antibodies in HSE, ME/CFS, Long Covid.
    Patients affected by neurocognitive issues e.g. in HSE have auto antibodies against NMDA receptors. I think the inference was that these are not found in ME/CFS. However, they have found (in conjunction with Carmen Scheibenbogen's lab in Germany) that ME/CFS patients have auto antibodies against muscarinic receptors (involved in acetylcholine signalling) and beta-adrenergic receptors (involved in adrenergic neurotransmission). Bergquist seems very certain that these autoantibodies are upregulated in the blood. However, they haven't found them in the CSF (I think that is the news).

    (Now, the muscarinic and beta-adrenergic auto antibodies finding was, I thought old news, and not very solid. In fact I have a memory (I might be wrong) of Scheibenbogen suggesting that rather than those autoantibodies being the defining feature of ME/CFS, it might be more that the receptors aren't working well for a range of reasons.)

    Bergquist is happy about not finding the auto antibodies in the CSF, because the blood can be relatively easily cleaned of the auto antibodies, whereas it is harder to remove auto antibodies from CSF. So treatments such as plasmapheresis and immune adsorption can be used. Bergquist suggested that experiments have been done of these treatments with some success.

    (Again, unless there has been a new study, I thought that success rates with these auto-antibody filtering treatments were underwhelming. I'd love this story to be true and maybe it is, but I don't think I've seen convincing evidence of it yet - and we've seen some evidence that suggests the idea is not right.)

    13 mins
    They have longitudinal samples (blood, urine, some CSF) from hospitalised patients with brain infections resulting from SARS-CoV2, other hospitalised patients with infections in other organs, and patients recovering from Covid-19 at home. There was some talk about what a unique opportunity the pandemic presents.

    26 mins
    What would Bergquist do to find the cure of ME/CFS if money was no object? - 'need to work even more on finding mechanisms, finding biomarkers, finding diagnostic, prognostic, therapeutic biomarkers' (Well, yes, that would be good.... But, I'd hope that the Chief Medical Officer of OMF might have shared some more specific ideas. And this need to work even more on finding mechanisms didn't seem to fit well with the expressed earlier certainty that there are specific auto-antibodies causing problems.)

    Bergquist suggested that there is sufficient understanding to start initiating small trials of interventions that could be relevant. He mentions auto-immunity again.

    [minor edits to fix typos]
     
    Last edited: May 30, 2022
    Lilas, cfsandmore, mango and 5 others like this.
  9. Braganca

    Braganca Senior Member (Voting Rights)

    Messages:
    135
    Thanks @Hutan.

    Confused that he talked about studying patient populations that are not ME. Is the HSE study done in order to contribute to ME research in some way — as a comparison? Is that funded by OMF?

    Same with the hospitalized patients. I think that was funded by OMF even though it’s not likely to be typical of long Covid patients. i found that frustrating too.
     
    cfsandmore and Hutan like this.
  10. Hutan

    Hutan Moderator Staff Member

    Messages:
    20,122
    Location:
    Australia
    I had the same feeling. It would be good if researchers were clearer about where funding has come from for studies. I mean, I do understand that doing tangentially related studies can help fund infrastructure and staff, and help keep teams together. And results from those studies might happen to provide an insight relevant to ME/CFS. But, it would be good to know exactly which studies are OMF funded studies.
     

Share This Page