With respect to this thread https://www.s4me.info/threads/autoa...ic-fatigue-syndrome-2025-wohlrab-et-al.43586/
These are medications that lower IGG from 2 AI programs. I know some people don’t like it when I use these programs, but unfortunately I don’t know how to use the more sophisticated ones.
Chat GPT
Yes, certain medications and treatments can reduce or deplete total immunoglobulin G (IgG) levels. Here are the main categories and examples:
**1. Immunosuppressive and Chemotherapy Drugs**
These suppress the immune system and may reduce IgG production.
- **Corticosteroids** (e.g., prednisone, dexamethasone) – reduce lymphocyte activity, including B cells that produce IgG.
- **Cyclophosphamide** – cytotoxic to B cells.
- **Methotrexate** – inhibits DNA synthesis, affecting B cell function.
- **Azathioprine** – suppresses lymphocyte proliferation.
- **Mycophenolate mofetil** – inhibits purine synthesis in B and T cells.
- **Rituximab** – a monoclonal antibody that targets CD20+ B cells, directly reducing IgG production.
**2. Monoclonal Antibodies Targeting B Cells**
These are used in autoimmune diseases, cancers, and some transplant protocols.
- **Rituximab (Rituxan)** – depletes B cells (most common cause of secondary hypogammaglobulinemia).
- **Obinutuzumab**, **Ofatumumab**, and similar anti-CD20 agents – same mechanism as rituximab.
- **Daratumumab** – targets CD38 on plasma cells; used in multiple myeloma, reduces IgG.
- **Bortezomib** – proteasome inhibitor used in myeloma; suppresses plasma cell function.
-m **3. Immunosuppressive Biologics**
Used for autoimmune and inflammatory diseases.
- **TNF inhibitors** (e.g., infliximab, etanercept, adalimumab) – may reduce IgG in some individuals.
- **IL-6 inhibitors** (e.g., tocilizumab) – IL-6 is involved in B cell maturation.
- **Belimumab** – inhibits B cell activating factor (BAFF); reduces B cell survival.
**4. Plasma Exchange (Plasmapheresis)**
Physically removes IgG from the blood.
- Often used in conditions like myasthenia gravis or Guillain-Barré syndrome.
- Rapid, temporary depletion of circulating IgG.
**5. Other Treatments**
- **Radiation therapy** (especially total body irradiation) – can deplete B cells and reduce IgG over time.
- **Stem cell or bone marrow transplantation** – immune system "reset" can reduce or delay IgG recovery.
- **Long-term use of antiepileptics** (e.g., phenytoin, carbamazepine) – rarely, may reduce immunoglobulin levels.
---
Deep seek
Certainly! Several medications can reduce or deplete **total immunoglobulins (IgG)** by affecting B-cell function, suppressing the immune system, or increasing IgG catabolism. Here are some key drug classes and examples:
**1. Immunosuppressants & B-cell Depleting Agents**
- **Rituximab (anti-CD20 monoclonal antibody)** – Depletes B cells, leading to reduced IgG production.
- **Ocrelizumab, Ofatumumab (anti-CD20 therapies)** – Similar mechanism to rituximab.
- **Belimumab (anti-BAFF monoclonal antibody)** – Inhibits B-cell survival, lowering IgG over time.
**2. Corticosteroids (Prolonged High-Dose Use)**
- **Prednisone, Dexamethasone** – Can suppress B-cell function and IgG synthesis with long-term use.
**3. Alkylating Agents (Chemotherapy Drugs)**
- **Cyclophosphamide** – Suppresses B-cell proliferation, reducing IgG levels.
**4. Proteasome Inhibitors (Plasma Cell-Targeting Drugs)**
- **Bortezomib, Carfilzomib** – Used in multiple myeloma; can decrease IgG by killing plasma cells.
**5. mTOR Inhibitors**
- **Sirolimus (Rapamycin), Everolimus** – May reduce IgG by modulating B-cell activity.
**6. Other Immunomodulators**
- **Mycophenolate Mofetil (MMF)** – Inhibits B-cell proliferation, leading to lower IgG over time.
- **Azathioprine** – Suppresses B-cell function, potentially decreasing IgG.
**7. IVIG-Competing Therapies**
- **Imiglucerase (Enzyme Replacement Therapy in Gaucher’s Disease)** – Some reports suggest IgG reduction due to unknown mechanisms.
**Important Considerations:**
- IgG depletion is more common with **long-term use** of B-cell-depleting therapies (e.g., rituximab).
- Monitoring IgG levels is crucial in patients on these drugs, as **hypogammaglobulinemia** increases infection risk.
**IVIG (intravenous immunoglobulin) replacement** may be needed if IgG falls too low.
—————-
END AI
Interesting that phenytoin came up as there are some patients who reported significant improvements on this.
These are medications that lower IGG from 2 AI programs. I know some people don’t like it when I use these programs, but unfortunately I don’t know how to use the more sophisticated ones.
Chat GPT
Yes, certain medications and treatments can reduce or deplete total immunoglobulin G (IgG) levels. Here are the main categories and examples:
**1. Immunosuppressive and Chemotherapy Drugs**
These suppress the immune system and may reduce IgG production.
- **Corticosteroids** (e.g., prednisone, dexamethasone) – reduce lymphocyte activity, including B cells that produce IgG.
- **Cyclophosphamide** – cytotoxic to B cells.
- **Methotrexate** – inhibits DNA synthesis, affecting B cell function.
- **Azathioprine** – suppresses lymphocyte proliferation.
- **Mycophenolate mofetil** – inhibits purine synthesis in B and T cells.
- **Rituximab** – a monoclonal antibody that targets CD20+ B cells, directly reducing IgG production.
**2. Monoclonal Antibodies Targeting B Cells**
These are used in autoimmune diseases, cancers, and some transplant protocols.
- **Rituximab (Rituxan)** – depletes B cells (most common cause of secondary hypogammaglobulinemia).
- **Obinutuzumab**, **Ofatumumab**, and similar anti-CD20 agents – same mechanism as rituximab.
- **Daratumumab** – targets CD38 on plasma cells; used in multiple myeloma, reduces IgG.
- **Bortezomib** – proteasome inhibitor used in myeloma; suppresses plasma cell function.
-m **3. Immunosuppressive Biologics**
Used for autoimmune and inflammatory diseases.
- **TNF inhibitors** (e.g., infliximab, etanercept, adalimumab) – may reduce IgG in some individuals.
- **IL-6 inhibitors** (e.g., tocilizumab) – IL-6 is involved in B cell maturation.
- **Belimumab** – inhibits B cell activating factor (BAFF); reduces B cell survival.
**4. Plasma Exchange (Plasmapheresis)**
Physically removes IgG from the blood.
- Often used in conditions like myasthenia gravis or Guillain-Barré syndrome.
- Rapid, temporary depletion of circulating IgG.
**5. Other Treatments**
- **Radiation therapy** (especially total body irradiation) – can deplete B cells and reduce IgG over time.
- **Stem cell or bone marrow transplantation** – immune system "reset" can reduce or delay IgG recovery.
- **Long-term use of antiepileptics** (e.g., phenytoin, carbamazepine) – rarely, may reduce immunoglobulin levels.
---
Deep seek
Certainly! Several medications can reduce or deplete **total immunoglobulins (IgG)** by affecting B-cell function, suppressing the immune system, or increasing IgG catabolism. Here are some key drug classes and examples:
**1. Immunosuppressants & B-cell Depleting Agents**
- **Rituximab (anti-CD20 monoclonal antibody)** – Depletes B cells, leading to reduced IgG production.
- **Ocrelizumab, Ofatumumab (anti-CD20 therapies)** – Similar mechanism to rituximab.
- **Belimumab (anti-BAFF monoclonal antibody)** – Inhibits B-cell survival, lowering IgG over time.
**2. Corticosteroids (Prolonged High-Dose Use)**
- **Prednisone, Dexamethasone** – Can suppress B-cell function and IgG synthesis with long-term use.
**3. Alkylating Agents (Chemotherapy Drugs)**
- **Cyclophosphamide** – Suppresses B-cell proliferation, reducing IgG levels.
**4. Proteasome Inhibitors (Plasma Cell-Targeting Drugs)**
- **Bortezomib, Carfilzomib** – Used in multiple myeloma; can decrease IgG by killing plasma cells.
**5. mTOR Inhibitors**
- **Sirolimus (Rapamycin), Everolimus** – May reduce IgG by modulating B-cell activity.
**6. Other Immunomodulators**
- **Mycophenolate Mofetil (MMF)** – Inhibits B-cell proliferation, leading to lower IgG over time.
- **Azathioprine** – Suppresses B-cell function, potentially decreasing IgG.
**7. IVIG-Competing Therapies**
- **Imiglucerase (Enzyme Replacement Therapy in Gaucher’s Disease)** – Some reports suggest IgG reduction due to unknown mechanisms.
**Important Considerations:**
- IgG depletion is more common with **long-term use** of B-cell-depleting therapies (e.g., rituximab).
- Monitoring IgG levels is crucial in patients on these drugs, as **hypogammaglobulinemia** increases infection risk.
**IVIG (intravenous immunoglobulin) replacement** may be needed if IgG falls too low.
—————-
END AI
Interesting that phenytoin came up as there are some patients who reported significant improvements on this.
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