Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes, 2024, Scheiblich et al.

Discussion in 'Other health news and research' started by SNT Gatchaman, Aug 1, 2024.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
    Hannah Scheiblich; Frederik Eikens; Lena Wischhof; Sabine Opitz; Kay Jüngling; Csaba Cserép; Susanne V. Schmidt; Jessica Lambertz; Tracy Bellande; Balázs Pósfai; Charlotte Geck; Jasper Spitzer; Alexandru Odainic; Sergio Castro-Gomez; Stephanie Schwartz; Ibrahim Boussaad; Rejko Krüger; Enrico Glaab; Donato A. Di Monte; Daniele Bano; Ádám Dénes; Eike Latz; Ronald Melki; Hans-Christian Pape; Michael T. Heneka

    SUMMARY
    Microglia are crucial for maintaining brain health and neuron function. Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological and pathological conditions. These TNTs facilitate the rapid exchange of organelles, vesicles, and proteins. In neurodegenerative diseases like Parkinson's and Alzheimer's disease, toxic aggregates of alpha-synuclein (α-syn) and tau accumulate within neurons. Our research demonstrates that microglia use TNTs to extract neurons from these aggregates, restoring neuronal health. Additionally, microglia share their healthy mitochondria with burdened neurons, reducing oxidative stress and normalizing gene expression. Disrupting mitochondrial function with antimycin A before TNT formation eliminates this neuroprotection. Moreover, co-culturing neurons with microglia and promoting TNT formation rescues suppressed neuronal activity caused by α-syn or tau aggregates. Notably, TNT-mediated aggregate transfer is compromised in microglia carrying Lrrk22(Gly2019Ser) or Trem2(T66M) and (R47H) mutations, suggesting a role in the pathology of these gene variants in neurodegenerative diseases.


    Link | PDF (Neuron) [Open Access]
     
    Sean, duncan, Deanne NZ and 3 others like this.
  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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  3. Creekside

    Creekside Senior Member (Voting Rights)

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    Thanks, I forgot to post the paper by itself.
     
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