"In cell lines, mitochondrial Complex I expression (e.g., NDUFS2, NDUFB7, NDUFS6, etc.) also decreased in SARS-CoV-2 compared to IAV, IAVdNS1, HPIV, and RSV (Fig. 4C). As noted in primary cells, enrichment for oxidation–reduction metabolism was shared among all viral infections (i.e., SARS-CoV-2, HPIV, RSV, and IAV)."
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Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples - Scientific Reports
SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria...
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