Review Mitochondrial quality control pathways sense mitochondrial protein import, 2023, Laurie P. Lee-Glover and Timothy E. Shutt

Mitochondrial quality control pathways sense mitochondrial protein import
Laurie P. Lee-Glover; Timothy E. Shutt

Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous other metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins and the synthesis of 13 mitochondrial DNA-encoded proteins. A network of chaperones and proteases helps to fold new proteins and degrade unnecessary, damaged, or misfolded proteins, whereas more extensive damage can be removed by mitochondrial-derived vesicles (MDVs) or mitochondrial autophagy (mitophagy).

Here, focusing on mechanisms in mammalian cells, we review the importance of mitochondrial protein import as a sentinel of mitochondrial function that activates multiple MQC mechanisms when impaired.


Link | Paywall (Trends in Endocrinology & Metabolism)

 

Review article, concluding —