Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death, 2024, Wang et al.

Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death
Wang, Yunhe; Su, Binbin; Alcalde-Herraiz, Marta; Barclay, Nicola L.; Tian, Yaohua; Li, Chunxiao; Wareham, Nicholas J.; Paredes, Roger; Xie, Junqing; Prieto-Alhambra, Daniel

Effective prevention strategies for post-COVID complications are crucial for patients, clinicians, and policy makers to mitigate their cumulative burden.

This study evaluated the association of modifiable lifestyle factors (smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, and dietary habits) with COVID-19 multisystem sequelae, death, and hospitalization in the UK Biobank cohort (n = 68,896).

A favorable lifestyle (6-10 healthy factors; 46.4%) was associated with a 36% lower risk of multisystem sequelae (HR, 0.64; 95% CI, 0.58-0.69; ARR at 210 days, 7.08%; 95% CI, 5.98-8.09) compared to an unfavorable lifestyle (0-4 factors; 12.3%). Risk reductions spanned all 10 organ systems, including cardiovascular, coagulation, metabolic, gastrointestinal, kidney, mental health, musculoskeletal, respiratory disorders, and fatigue. This beneficial effect was largely attributable to direct lifestyle impacts independent of corresponding pre-infection comorbidities (71% for any sequelae).

A favorable lifestyle was also related to the risk of postCOVID death (HR 0.59, 0.52-0.66) and hospitalization (HR 0.78, 0.73-0.84). These associations persisted across acute and post-acute infection phases, irrespective of hospitalization status, vaccination, or SARS-CoV-2 variant.

These findings underscore the clinical and public health importance of adhering to a healthy lifestyle in mitigating long-term COVID-19 adverse impacts and enhancing future pandemic preparedness.

Link | PDF (Nature Communications) [Open Access]

 

The irony of talking about modifiable lifestyle factors when everyone is encouraged by public health authorities to spread infectious illnesses like it's a competition.

Because the main factor here, the one that offers 100% protection, is... not catching COVID. And people are pretty much literally encouraged to catch it as often as possible because it's good for their health. By the same authorities who want to be taken seriously when they talk about diet and exercise. Orwell could not have come up with such a giant dumpster fire if he tried. Human folly is far more creative than speculative fiction.

All it does is give me an image of some doctor coaching a group of people at exercise, while smoking, a drink in hand and all in heavy polluted air that is far too hot for strenuous exercise. It's all so damn dysfunctional and broken.

 

Yep.

 

…How healthy a lifestyle is one able to create and maintain whilst totally mentally and physically fucked from a previous COVID-19 infection, living in poverty and socially shunned because your illness either doesn’t exist or if it does is your fault for not manning up and getting a better immune system.

I can’t take anyone talking about lifestyle factors seriously there’s the theory or strong suspicion that this is always a malevolent framework to utilise and then there’s living during a never ending pandemic and watching how in but two years everybody forgot all about infection control and doubled down on the lifestyle control.