Musculoskeletal Pain in Individuals with Inflammatory Bowel Disease Reflects Three Distinct Profiles, 2019, Falling et al

Andy · Mar 9, 2019

Abstract
OBJECTIVES:
Pain affects over 70% of individuals with inflammatory bowel disease (IBD), with abdominal and musculoskeletal pain representing the most common complaints. Musculoskeletal pain in IBD is reported to be associated with multiple clinical features, however the scope and nature of pain is not well understood. Primary aims were to identify subgroups of musculoskeletal pain in individuals with IBD based on clinical features of pain, and assess how these subgroups differ in aspects of demographics, comorbidity, and IBD characteristics.

METHODS:
Cross-sectional online survey was performed on adults with IBD. Domains included: demographics, comorbidity, and clinical IBD and pain features. Latent class analysis was used to identify subgroups with similar attributes of: pain (severity, location, interference, and quality), IBD (activity, quality of life, and abdominal pain), and symptoms related to central sensitization. Correlation and regression analyses were used to profile identified subgroups.

RESULTS:
Of 305 included participants, 208 indicated the presence of musculoskeletal pain. Three identified subgroups were characterized as "mixed mechanism", "central mechanism", and "regional & remission". Between subgroup differences included: total comorbidity score (P=0.005), osteoarthritis (P=0.027), osteoporosis (P=0.045), depression (P=0.001), anxiety (P=0.025), and chronic fatigue syndrome (P=0.020). Gender and age were identified as confounders for depression and anxiety.

CONCLUSION:
Study results suggest multiple mechanisms contributing to pain experiences in IBD, to include central mechanisms. Features related to demographics, extraintestinal manifestations, IBD subtype, and clinical IBD features were not predictors of subgroup membership. However, total comorbidity demonstrated association with pain subgroups in this population.
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Paywalled at https://journals.lww.com/clinicalpa...oskeletal_Pain_in_Individuals_with.98854.aspx

Jonathan Edwards · Mar 9, 2019

I find it hard to believe that people are writing this sort of stuff. We know there are distinct profiles of musculoskeletal pain in people with IBD and have done for decades - they include a specific peripheral colitic arthropathy, IBD-assocaited spondylitis, and usual mechanical joint problems. If these are not identified for starters then I see no point in inventing mumbo-jumbo about central mechanisms.

Trish · Mar 9, 2019

extraintestinal manifestations
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I read that as extraterrestrial manifestations.

rvallee · Mar 10, 2019

Trish said: ↑

I read that as extraterrestrial manifestations.
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Musculoskeletal Pain in Individuals with Inflammatory Bowel Disease Reflects Three Distinct Profiles, 2019, Falling et al

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Musculoskeletal Pain in Individuals with Inflammatory Bowel Disease Reflects Three Distinct Profiles, 2019, Falling et al

Andy Committee Member

Jonathan Edwards Senior Member (Voting Rights)

Trish Moderator Staff Member

rvallee Senior Member (Voting Rights)

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