NeuroSPECT assessment of abnormal distribution of rcbf in CFIDS vs "autistic syndrome children", ?, Goldberg
- Thread starter Dolphin
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- cerebral blood flow
This paper seems to show the same data for CFS, but without the inclusion of autism data:
NeuroSPECT Findings in Children with Chronic Fatigue Syndrome
Goldberg, Michael J.; Mena, Ismael; Darcourt, Jacques
Abstract
Background
NeuroSPECT studies have described specific abnormalities in cerebral perfusion in adults with criteria for Chronic Fatigue Syndrome. This reports findings in 13 children with criteria for Chronic Fatigue Syndrome.
Objective
NeuroSPECT findings in 13 CFS/CFIDS children.
Methods
Thirteen children meeting CDC criteria for CFS/CFIDS, were evaluated using NeuroSPECT imaging utilizing Xenon 133 and Tc-99m-HMPAO(l).
Results
In 13 children, hypopcrfusion was observed at 42 ± 10 ml/min/100g, p < 0.0001 in the left temporal lobe and at 45 ± 11, p < .001 in right temporal lobe. Statistically significant hypoperfusion was also observed in both parietal lobes and at 50 and 53 ml/ min/lOOg, p < 0.05 in the frontal lobe of the right hemisphere. Quantitated HMPAO demonstrated bilateral orbitofrontal and anterior temporal hypoperfusion. There was also hypoperfusion in the dorsal aspects of both frontal lobes and both parietooccipital lobes.
Conclusion
NeuroSPECT is presented as a quantifiable, reproducible tool that can allow us to document a cohort of children defined as CFS/CFIDS.
Web | DOI | Journal of Chronic Fatigue Syndrome | 2011 | Paywall
NeuroSPECT Findings in Children with Chronic Fatigue Syndrome
Goldberg, Michael J.; Mena, Ismael; Darcourt, Jacques
Abstract
Background
NeuroSPECT studies have described specific abnormalities in cerebral perfusion in adults with criteria for Chronic Fatigue Syndrome. This reports findings in 13 children with criteria for Chronic Fatigue Syndrome.
Objective
NeuroSPECT findings in 13 CFS/CFIDS children.
Methods
Thirteen children meeting CDC criteria for CFS/CFIDS, were evaluated using NeuroSPECT imaging utilizing Xenon 133 and Tc-99m-HMPAO(l).
Results
In 13 children, hypopcrfusion was observed at 42 ± 10 ml/min/100g, p < 0.0001 in the left temporal lobe and at 45 ± 11, p < .001 in right temporal lobe. Statistically significant hypoperfusion was also observed in both parietal lobes and at 50 and 53 ml/ min/lOOg, p < 0.05 in the frontal lobe of the right hemisphere. Quantitated HMPAO demonstrated bilateral orbitofrontal and anterior temporal hypoperfusion. There was also hypoperfusion in the dorsal aspects of both frontal lobes and both parietooccipital lobes.
Conclusion
NeuroSPECT is presented as a quantifiable, reproducible tool that can allow us to document a cohort of children defined as CFS/CFIDS.
Web | DOI | Journal of Chronic Fatigue Syndrome | 2011 | Paywall