D
Deleted member 2545
Guest
Findings were
- low number of NK cells
- increased neutrophils that are misshapen
- macrophage involvement
The actual research the article was prompted by:
Last edited by a moderator:
Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development, 2025, Wilson et al
Findings were
- low number of NK cells
- increased neutrophils that are misshapen
- macrophage involvement
The actual research the article was prompted by:
Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development
Taylor R Wilson; Kurt R Peterson; Stephanie A Morris; Damaris Kuhnell; Susan Kasper; Katherine A Burns
Endometriosis is a chronic gynecological disease that affects 1 in 10 reproductive-aged women. Most studies investigate established disease; however, the initiation and early events in endometriotic lesion development remain poorly understood.
Our study used neutrophils from human menstrual effluent from patients with and without endometriosis for immunophenotyping, and it used a mouse model of endometriosis and a mouse endometriosis cell line to determine the role of neutrophils in the initiating events of endometriosis, including attachment and survival of minced endometrial pieces.
In menstrual effluent from women with endometriosis, the ratios of aged and proangiogenic neutrophils increased compared with controls, indicating a potentially permissive proinflammatory microenvironment. In our endometriosis mouse model, knocking down neutrophil recruitment with α-CXCR2 into the peritoneum decreased endometrial tissue adhesion — supported by decreased levels of myeloperoxidase and neutrophil elastase in both developing lesions and peritoneal fluid. Fibrinogen was identified as the preferred substrate for endometrial cell adhesion in an in vitro adhesion assay and in developing lesions in vivo.
Together, aged and proangiogenic neutrophils and their secretions likely promote attachment and formation of endometriotic lesions by releasing neutrophil extracellular traps and upregulating fibrinogen expression as a provisional matrix to establish attachment and survival in the development of endometriosis lesions.
Web | PDF | JCI Insight | Open Access
Jonathan Edwards
Senior Member (Voting Rights)
I don't know what they mean by 'early immune mechanisms' here. It all seems a bit divorced from in vivo reality. I can't see what it would have to do with the RNA stuff to be honest.