New Study Will Assess Tysabri Effects on MS Cognitive Fatigue

Jaybee00 · May 29, 2021

https://multiplesclerosisnewstoday....apsing-remitting-multiple-sclerosis-patients/

Mij · May 29, 2021

So it appears that Tysabri has been rejected by the FDA?

edit:

It appears that the sub q not the intravenous administration has been rejected.

Mij · May 29, 2021

Abstract
Background
Optimizing multiple sclerosis treatment warrants understanding of changes in physical, mental, and social health.

Objective
To assess the impact of natalizumab on Quality of Life in Neurological Disorders (Neuro-QoL) scores.

Methods
Annualized change in T-scores and likelihood of ≥5-point improvement over baseline were calculated for each Neuro-QoL domain after natalizumab initiation. Comparisons with ocrelizumab-treated patients were conducted after propensity score weighting and adjustment for relevant co-medications, year, and drug-year interaction.

Results
Among 164 natalizumab patients analyzed, 8 of 12 Neuro-QoL domains improved significantly, with greater improvement in patients with abnormal baseline Neuro-QoL. In the subgroup comparison of natalizumab-treated (n = 145) and ocrelizumab-treated (n = 520) patients, significant improvement occurred in 9 of 12 and 4 of 12 domains, respectively. The difference between groups was statistically significant for positive affect and well-being (p = 0.02), sleep (p = 0.003), and satisfaction with social roles and activities (SRA) (p = 0.03) in the overall population and for emotional and behavioral dyscontrol (p = 0.01), participation in SRA (p = 0.0001), and satisfaction with SRA (p = 0.02) in patients with abnormal baseline Neuro-QoL.

Conclusions
Natalizumab can produce clinically meaningful improvements in mental and social health. Such improvements are unlikely to be primarily driven by expectation bias, as their magnitude exceeded improvements with another high-efficacy therapy, ocrelizumab.
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https://journals.sagepub.com/doi/full/10.1177/20552173211004634

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New Study Will Assess Tysabri Effects on MS Cognitive Fatigue

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New Study Will Assess Tysabri Effects on MS Cognitive Fatigue

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