multiple sclerosis

Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID (LC19)...

EBV Reprograms B Cells in an Autoimmune-Like Fashion in Patients with COVID-19 Epstein-Barr virus (EBV) reprograms B cells in autoimmune disease. Reprogrammed EBV+ B cells activate nearby B and CD4+ T cells, via upregulated antigen presentation and costimulatory machinery, to drive autoimmune...

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity Abstract Astrocytes contribute to the pathology of multiple neurological disorders, including the T cell-driven autoimmune disease of the central nervous system (CNS) multiple sclerosis and its mouse model, experimental...

As a lot of the genetic evidence points towards synapses, one very simple hypothesis is a general and randomised loss of synapses throughout the nervous system. I want to vent a few disorganised thoughts and questions I have about that here. Tell me if it sounds implausible. ----------------...

Localized PD-1 CAR T therapy reprograms neuroinflammation Highlights • Single-cell modeling identifies disease-associated immune circuits in MS CNS tissue • PD-1+ Tfh-like cells mark a pathogenic T cell-B cell axis in MS • PD-1 CAR T cells deplete pathogenic CD4 T cells and suppress...

CD4 + T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis Editor’s summary Epstein-Barr virus (EBV) has been nearly definitively linked to development of multiple sclerosis (MS); however, the exact roles of EBV itself and the immune...

Chronic fatigue syndrome in MS: an endogenous response pattern to an immunological challenge mediated by orexin/hypocretin? Hildebrandt, Helmut; Stuke, Heiner Abstract Fatigue is a common and disabling symptom in patients with inflammatory or autoimmune diseases like Multiple Sclerosis...

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy Abstract Cytokine effects on behavior may be related to alterations in glutamate metabolism. We therefore measured glutamate concentrations in brain regions shown to be affected by...

EEG-based frontal excitation/inhibition balance as an objective biomarker for cognitive fatigue across multiple sclerosis and Long COVID BACKGROUND Cognitive fatigue is a prevalent and disabling symptom in neurological and post-viral conditions, including multiple sclerosis (MS) and Long...

Abstract Multiple sclerosis (MS) occurs when the central nervous system (CNS) is damaged by misguided adaptive immune responses, likely caused by a combination of environmental factors in genetically susceptible individuals. A known prerequisite for disease is Epstein-Barr virus (EBV)...

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In...

Neurological sequela of COVID-19 in adults with multiple sclerosis BACKGROUND Possible interactions in neuropsychiatric presentations of multiple sclerosis (MS) and COVID-19 may occur, which has been proposed in previous, albeit limited, literature. OBJECTIVES Examine COVID-19 disease...

full article: https://www.news-medical.net/news/20251230/Periodontal-bacterial-load-associated-with-disease-severity-in-multiple-sclerosis.aspx

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis Abstract Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and is associated with the risk of disease activity, but data on the benefits of supplementation are conflicting. Objective...

Vitamin D intake and multiple sclerosis risk in the Norwegian Mother, Father and Child cohort BACKGROUND Higher vitamin D has consistently been associated with a lower multiple sclerosis (MS) risk, but some controversy remains about whether this is due to vitamin D itself or sunlight. METHODS...

https://www.news-medical.net/news/20251022/People-with-multiple-sclerosis-found-to-have-dysbiotic-oral-microbiome.aspx

Normal appearing white matter and disability in multiple sclerosis BACKGROUND AND OBJECTIVES Multiple sclerosis (MS) is characterized by lesions and atrophy on conventional MRI, yet these often fail to explain disability. Diffusion MRI (dMRI) detects microstructural injury with diffusion...

https://www.news-medical.net/news/20251107/New-method-promises-to-alleviate-the-symptoms-of-multiple-sclerosis.aspx

Characterizing post-COVID-19 syndrome in multiple sclerosis: Vaccine status, infection burden, and therapy categories as predictors Deepak Sharma ∙ Christian P. Kamm ∙ Robert Hoepner ∙ Iris-Katharina Penner ∙ Thomas Nyffeler ∙ Lara Diem [Line breaks added] Background Post-COVID-19 syndrome...

https://www.msn.com/en-gb/health/medical/biology-teacher-becomes-first-uk-patient-to-receive-gamechanger-therapy-for-ms/ar-AA1P4nc7?ocid=msedgntp&pc=U531&cvid=68fb7249618f479794914ca2e693c6df&ei=10 https://www.independent.co.uk/news/health/multiple-sclerosis-gamechanger-therapy-nhs-b2850928.html