News in Brief - January 2026
- Thread starter S4ME News
- Start date
-
- Tags
- news news in brief
Week beginning 29th December 2025
Wishing all our readers a Happy New Year!
News, advocacy and articles
The Journal of the Norwegian Medical Association CFS/ME - from hysteria to biomedical illness
Opinion piece by Ola Didrik Saugstad, Donia Jamal Ramadan and Marte Kathrine Viken on recent hypotheses and findings from research into ME. The authors say that the public health system needs to take a much larger responsibility for this patient group and that patients must be met with knowledge and respect.
Article (Norwegian) - Thread
Trial by Error by David Tuller
Journal Published Confusing Section on "Enduring Symptoms"
"As part of its December issue, Future Healthcare Journal, sponsored by the UK’s Royal College of Physicians, has published a special section called “Challenging Myths: Debunking Functional Disorders.” The special section title itself creates confusion. In what way are functional disorders being “debunked”? I assume the idea is to debunk the purported “myths” about functional disorders, whatever they are—but that’s not what the words mean in this combination."
Article l Thread
My Unexpected E-Mail Exchange with Alem Matthees
Australian Alem Matthees, a key contributor to the debunking of the PACE trial and a very severe ME patient for many years, has shared with Tuller the welcome news of a slight improvement. He is able to do a bit of writing and wishes to eventually write articles about what he has experienced.
Article l Thread
UK LBC Treatment for ME has turned a corner - the UK must not leave patients waiting
"Let’s make this the decade we finally develop treatments for this condition, writes Sonya Chowdhury. For too long, those living with [ME/CFS] have had to live with disbelief." Chowdhury highlights the DecodeME results and the need for further research funding. "Action for ME is calling for the creation of a Strategic Research Hub for ME, to ensure that recent scientific progress translates into meaningful treatments."
Article | Thread
Video essay On hope and chronic illness.
Jonathan, who has had ME/CFS since age 14, describes vividly his experiences with a series of damaging alternative and medical treatments, and the importance of getting a diagnosis after 6 years of misdiagnosis. He discusses the importance of hope, but, says: "I had no idea that the world of illness was so full of predators. They’d dispute that label, but they harm desperate people by offering false hope".
Video (16 minutes) | Article | Thread
Blog: The Red Tree and M.E. by Dr Jo Greer
"As an educational psychologist working with children in care in the UK, I often used therapeutic stories in my practice. I especially loved The Red Tree by Shaun Tan".
" Amidst the disconcertingly dark imagery in The Red Tree, the recurring motif of the red leaf offers peace and assurance as it speaks to hope."
Carer for her daughter with very severe ME, Dr Greer has developed her articles into an advocacy project described in this series of blog articles.
Article | Thread
Aotearoa New Zealand ANZMES Survey
Open to NZ members and non-members. "As we transition to a Charitable Trust and look toward the future, we want to ensure our goals align with the reality of what you expect."
Survey | Thread
........
Coming events
Bateman Horne Center – Free Online Support Group
Tuesday, January 6, 1:00 - 2:00 PM Mountain Time
Topic: To Be Announced
Advance registration required, see thread for times in your time zone.
Event Calendar | Thread
UK The ME Association will hold its Annual General Meeting (AGM) on 12 January 2026 at 2:00 pm. Members of the charity are invited to attend either in person at the Head Office or via an online video conference link.
Article | Thread
Solve ME Webinar – From Mystery to Measurable: The Science Behind the New ME/CFS Blood Test
Discussion of the new blood-based assay, the EpiSwitch CFS test, and its potential impact on diagnosing and treating people with ME/CFS and Long Covid.
Thursday, January 15, 9 AM Pacific Time.
Announcement | Registration | Thread
Webinar: PRIME Workshop How AI/ML methods can enhance ME/CFS molecular or genetic biomarker discovery, Jan 21, 2026, 02:00 to 05:00 PM (GMT)
"The aim of this workshop is to present state-of-the-art quantitative methodologies that have been, or could be, applied in the context of ME/CFS and LC to motivate and empower researchers to take on and apply promising techniques in their own work in this area." Recording of the event will be made available afterwards.
Registration | Thread
........
Research news and commentary
Promising medicines for ME/CFS: call for drug repurposing. The Dutch funding agency ZonMw has issued a new call on drug repurposing or rediscovery for patients with ME/CFS. It aims to fund projects focused on clinical research into the effectiveness of an existing medicine (off-patent, available in the Netherlands) as a new application. The budget is € 3,5 million.
Article | Thread
2025: looking back on a year of ME/CFS research. ME/CFS Science Blog has published a review of the most interesting ME/CFS studies in 2025, including DecodeME, the daratumumab trial, autopsy findings from the Netherlands, and most extensive study on antibodies in ME/CFS to date.
Article | Thread
ME Research UK 2024/25 – Our Charity Year in Review
The review describes the work of MERUK under the headings Our Vision and Mission, Investing, Informing and Influencing.
Article | Thread
Journal of Family Medicine Letter to editor regarding the lightning process
Nina E. Steinkopf clarifies that a previously published article by Arroll et al. is not a clinical audit, but is research that has been undertaken and published without ethics approval. "I trust that you will ensure the correction of this error to uphold the integrity of your journal."
Letter | Thread
........
Research
ME/CFS research
Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome— Helena M. Huhmar et al.
"Our results reveal a high prevalence of low P-VP, low urine osmolality and high plasma osmolality after overnight water restriction." "The high incidence of low VP in our patient cohort suggests that chronic down-regulation of VP secretion may be an elementary part of pathophysiology of ME/CFS"
Article | Thread
Sustained illness burden over time among Australians with myalgic encephalomyelitis/chronic fatigue syndrome — Breanna Weigel et al.
"Importantly, no significant differences were observed in any measure of symptom presentation, overall perceptions of health status, QoL, functional capacity or fatigue impact over the 12-month study period." "the present study highlights that the profound impacts on the health and wellbeing of pwME/CFS are persistent and long-term." "Moreover, this study captured the lived experiences of pwME/CFS with established illness, as most participants had lived with a diagnosis of ME/CFS for at least one decade."
Article | Thread
Characterization of Post-Viral Infection Behaviors Among Patients With Long COVID: Prospective, Observational, Longitudinal Cohort Analyses of Fitbit Data and Patient-Reported Outcomes — Tianmai M Zhang
"Our finding that a lower [moderate-vigorous physical activity] level was associated with more improvements in outcomes in the long-term seems to suggest some benefit from reduced activity."
Article | Thread
Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance — Tiff-Annie Kenny
"While the narrative arc, structure, and analysis are shaped by the author’s lived experience as an affected patient, the arguments are grounded in a synthesis of peer-reviewed literature, regulatory reviews, and case-based evidence." "This perspective has enabled the discussion of structural and epistemic limitations that warrant urgent attention."
Article | Thread
Supporting people with myalgic encephalomyelitis in primary care — Sonya Chowdhury
"ME is not rare, nor is it going away. People with ME need recognition, compassion and commitment from every corner of the healthcare system. For general practice nurses, this starts with listening, understanding the nature of the illness and supporting patients through the long journey of managing their symptoms."
Article | Thread
Long Covid research
Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue — Maria Germann et al.
"we found evidence for autonomic dysfunction (decreased blood oxygen saturation, increased heart rate and decreased heart rate variability), increased peripheral muscle fatigue and a reduction in intracortical facilitation (ICF), a measure of intracortical glutamatergic function. There was also an increase in body weight, though notably it was mainly the percentage of muscle mass that appeared to increase."
Preprint | Thread
SARS-CoV-2 Infection Is Associated With an Increased Risk of Hospital-Treated Infectious Mononucleosis due to EBV: National Register-Based Cohort Study — Snieguole Vingeliene et al.
"In this national study, SARS‐CoV‐2 infection was notably associated with an increased risk for subsequent EBV‐IM." "A positive PCR test without hospital admission, which occurred in a larger number of individuals, was associated with a higher risk of subsequent EBV‐IM, compared with individuals who did not have a registered positive PCR test for SARS‐CoV‐2 infection."
Article | Thread
Beyond COVID-19 in people with HIV: Specific miRNA expression profile persist after SARS-CoV-2 clearance — Grande-García et al.
"our findings reveal a persistent alteration of circulating miRNAs in [people with HIV] following SARS-CoV-2 infection after 4 weeks, suggesting an epigenetic imprinting that may contribute to the development of post-COVID conditions."
Article | Thread
Autoantibodies in long COVID in a black/mixed population compared with recovered and pre-pandemic controls — de Jesus Silva et al.
"The lack of association between these autoantibody profiles and clinical manifestations of long COVID indicates that, if present, the contribution of autoantibodies to symptom persistence is likely modest."
Article | Thread
Understanding how social determinants of health shape Long COVID outcomes: a rapid review of evidence — Tamim El Jarkass et al.
"This review synthesizes evidence from 71 studies across multiple countries, providing one of the most comprehensive evaluations to date of the relationship between social determinants of health and Long COVID." "We found that individuals in frontline and public-facing roles appear to face an elevated risk, likely reflecting greater exposure to SARS-CoV-2 and subsequent susceptibility to persistent symptoms."
Article | Thread
Post-Covid-19 symptoms, subjective work ability and sick leave 2 years after acute infection—results from a population-based long COVID study — Braig et al.
"In our population-based cohort study, 1.1% of participants had been continuously on sick leave since the initial infection, while 3.7% experienced recurrent sick leave at 24 months."
Article | Thread
Post-translational modifications within fibrinaloid microclot complexes distinguish Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome, Long COVID, and Long COVID-POTS and reveal disease-specific molecular pathways — Renata Madre Booyens et al.
"PTM profiling reveals distinct yet overlapping biochemical signatures invisible to standard blood tests" "Long COVID exhibits pro-coagulant fibrinogen modifications with metabolic dysregulation. PC-POTS and LC-POTS shows predominantly immune-oxidative disruptions"
Preprint | Thread
...........
S4ME social media: Forum, Mastodon, Bluesky
Wishing all our readers a Happy New Year!News, advocacy and articles
The Journal of the Norwegian Medical Association CFS/ME - from hysteria to biomedical illness
Opinion piece by Ola Didrik Saugstad, Donia Jamal Ramadan and Marte Kathrine Viken on recent hypotheses and findings from research into ME. The authors say that the public health system needs to take a much larger responsibility for this patient group and that patients must be met with knowledge and respect.
Article (Norwegian) - Thread
Trial by Error by David Tuller
Journal Published Confusing Section on "Enduring Symptoms"
"As part of its December issue, Future Healthcare Journal, sponsored by the UK’s Royal College of Physicians, has published a special section called “Challenging Myths: Debunking Functional Disorders.” The special section title itself creates confusion. In what way are functional disorders being “debunked”? I assume the idea is to debunk the purported “myths” about functional disorders, whatever they are—but that’s not what the words mean in this combination."
Article l Thread
My Unexpected E-Mail Exchange with Alem Matthees
Australian Alem Matthees, a key contributor to the debunking of the PACE trial and a very severe ME patient for many years, has shared with Tuller the welcome news of a slight improvement. He is able to do a bit of writing and wishes to eventually write articles about what he has experienced.
Article l Thread
UK LBC Treatment for ME has turned a corner - the UK must not leave patients waiting
"Let’s make this the decade we finally develop treatments for this condition, writes Sonya Chowdhury. For too long, those living with [ME/CFS] have had to live with disbelief." Chowdhury highlights the DecodeME results and the need for further research funding. "Action for ME is calling for the creation of a Strategic Research Hub for ME, to ensure that recent scientific progress translates into meaningful treatments."
Article | Thread
Video essay On hope and chronic illness.
Jonathan, who has had ME/CFS since age 14, describes vividly his experiences with a series of damaging alternative and medical treatments, and the importance of getting a diagnosis after 6 years of misdiagnosis. He discusses the importance of hope, but, says: "I had no idea that the world of illness was so full of predators. They’d dispute that label, but they harm desperate people by offering false hope".
Video (16 minutes) | Article | Thread
Blog: The Red Tree and M.E. by Dr Jo Greer
"As an educational psychologist working with children in care in the UK, I often used therapeutic stories in my practice. I especially loved The Red Tree by Shaun Tan".
" Amidst the disconcertingly dark imagery in The Red Tree, the recurring motif of the red leaf offers peace and assurance as it speaks to hope."
Carer for her daughter with very severe ME, Dr Greer has developed her articles into an advocacy project described in this series of blog articles.
Article | Thread
Aotearoa New Zealand ANZMES Survey
Open to NZ members and non-members. "As we transition to a Charitable Trust and look toward the future, we want to ensure our goals align with the reality of what you expect."
Survey | Thread
........
Coming events
Bateman Horne Center – Free Online Support Group
Tuesday, January 6, 1:00 - 2:00 PM Mountain Time
Topic: To Be Announced
Advance registration required, see thread for times in your time zone.
Event Calendar | Thread
UK The ME Association will hold its Annual General Meeting (AGM) on 12 January 2026 at 2:00 pm. Members of the charity are invited to attend either in person at the Head Office or via an online video conference link.
Article | Thread
Solve ME Webinar – From Mystery to Measurable: The Science Behind the New ME/CFS Blood Test
Discussion of the new blood-based assay, the EpiSwitch CFS test, and its potential impact on diagnosing and treating people with ME/CFS and Long Covid.
Thursday, January 15, 9 AM Pacific Time.
Announcement | Registration | Thread
Webinar: PRIME Workshop How AI/ML methods can enhance ME/CFS molecular or genetic biomarker discovery, Jan 21, 2026, 02:00 to 05:00 PM (GMT)
"The aim of this workshop is to present state-of-the-art quantitative methodologies that have been, or could be, applied in the context of ME/CFS and LC to motivate and empower researchers to take on and apply promising techniques in their own work in this area." Recording of the event will be made available afterwards.
Registration | Thread
........
Research news and commentary
Promising medicines for ME/CFS: call for drug repurposing. The Dutch funding agency ZonMw has issued a new call on drug repurposing or rediscovery for patients with ME/CFS. It aims to fund projects focused on clinical research into the effectiveness of an existing medicine (off-patent, available in the Netherlands) as a new application. The budget is € 3,5 million.
Article | Thread
2025: looking back on a year of ME/CFS research. ME/CFS Science Blog has published a review of the most interesting ME/CFS studies in 2025, including DecodeME, the daratumumab trial, autopsy findings from the Netherlands, and most extensive study on antibodies in ME/CFS to date.
Article | Thread
ME Research UK 2024/25 – Our Charity Year in Review
The review describes the work of MERUK under the headings Our Vision and Mission, Investing, Informing and Influencing.
Article | Thread
Journal of Family Medicine Letter to editor regarding the lightning process
Nina E. Steinkopf clarifies that a previously published article by Arroll et al. is not a clinical audit, but is research that has been undertaken and published without ethics approval. "I trust that you will ensure the correction of this error to uphold the integrity of your journal."
Letter | Thread
........
Research
ME/CFS research
Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome— Helena M. Huhmar et al.
"Our results reveal a high prevalence of low P-VP, low urine osmolality and high plasma osmolality after overnight water restriction." "The high incidence of low VP in our patient cohort suggests that chronic down-regulation of VP secretion may be an elementary part of pathophysiology of ME/CFS"
Article | Thread
Sustained illness burden over time among Australians with myalgic encephalomyelitis/chronic fatigue syndrome — Breanna Weigel et al.
"Importantly, no significant differences were observed in any measure of symptom presentation, overall perceptions of health status, QoL, functional capacity or fatigue impact over the 12-month study period." "the present study highlights that the profound impacts on the health and wellbeing of pwME/CFS are persistent and long-term." "Moreover, this study captured the lived experiences of pwME/CFS with established illness, as most participants had lived with a diagnosis of ME/CFS for at least one decade."
Article | Thread
Characterization of Post-Viral Infection Behaviors Among Patients With Long COVID: Prospective, Observational, Longitudinal Cohort Analyses of Fitbit Data and Patient-Reported Outcomes — Tianmai M Zhang
"Our finding that a lower [moderate-vigorous physical activity] level was associated with more improvements in outcomes in the long-term seems to suggest some benefit from reduced activity."
Article | Thread
Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance — Tiff-Annie Kenny
"While the narrative arc, structure, and analysis are shaped by the author’s lived experience as an affected patient, the arguments are grounded in a synthesis of peer-reviewed literature, regulatory reviews, and case-based evidence." "This perspective has enabled the discussion of structural and epistemic limitations that warrant urgent attention."
Article | Thread
Supporting people with myalgic encephalomyelitis in primary care — Sonya Chowdhury
"ME is not rare, nor is it going away. People with ME need recognition, compassion and commitment from every corner of the healthcare system. For general practice nurses, this starts with listening, understanding the nature of the illness and supporting patients through the long journey of managing their symptoms."
Article | Thread
Long Covid research
Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue — Maria Germann et al.
"we found evidence for autonomic dysfunction (decreased blood oxygen saturation, increased heart rate and decreased heart rate variability), increased peripheral muscle fatigue and a reduction in intracortical facilitation (ICF), a measure of intracortical glutamatergic function. There was also an increase in body weight, though notably it was mainly the percentage of muscle mass that appeared to increase."
Preprint | Thread
SARS-CoV-2 Infection Is Associated With an Increased Risk of Hospital-Treated Infectious Mononucleosis due to EBV: National Register-Based Cohort Study — Snieguole Vingeliene et al.
"In this national study, SARS‐CoV‐2 infection was notably associated with an increased risk for subsequent EBV‐IM." "A positive PCR test without hospital admission, which occurred in a larger number of individuals, was associated with a higher risk of subsequent EBV‐IM, compared with individuals who did not have a registered positive PCR test for SARS‐CoV‐2 infection."
Article | Thread
Beyond COVID-19 in people with HIV: Specific miRNA expression profile persist after SARS-CoV-2 clearance — Grande-García et al.
"our findings reveal a persistent alteration of circulating miRNAs in [people with HIV] following SARS-CoV-2 infection after 4 weeks, suggesting an epigenetic imprinting that may contribute to the development of post-COVID conditions."
Article | Thread
Autoantibodies in long COVID in a black/mixed population compared with recovered and pre-pandemic controls — de Jesus Silva et al.
"The lack of association between these autoantibody profiles and clinical manifestations of long COVID indicates that, if present, the contribution of autoantibodies to symptom persistence is likely modest."
Article | Thread
Understanding how social determinants of health shape Long COVID outcomes: a rapid review of evidence — Tamim El Jarkass et al.
"This review synthesizes evidence from 71 studies across multiple countries, providing one of the most comprehensive evaluations to date of the relationship between social determinants of health and Long COVID." "We found that individuals in frontline and public-facing roles appear to face an elevated risk, likely reflecting greater exposure to SARS-CoV-2 and subsequent susceptibility to persistent symptoms."
Article | Thread
Post-Covid-19 symptoms, subjective work ability and sick leave 2 years after acute infection—results from a population-based long COVID study — Braig et al.
"In our population-based cohort study, 1.1% of participants had been continuously on sick leave since the initial infection, while 3.7% experienced recurrent sick leave at 24 months."
Article | Thread
Post-translational modifications within fibrinaloid microclot complexes distinguish Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome, Long COVID, and Long COVID-POTS and reveal disease-specific molecular pathways — Renata Madre Booyens et al.
"PTM profiling reveals distinct yet overlapping biochemical signatures invisible to standard blood tests" "Long COVID exhibits pro-coagulant fibrinogen modifications with metabolic dysregulation. PC-POTS and LC-POTS shows predominantly immune-oxidative disruptions"
Preprint | Thread
...........
S4ME social media: Forum, Mastodon, Bluesky
Week beginning 5th January 2026
News, advocacy and articles
UK ME Association Healthcare Team releases their annual report for 2025
“This report presents the findings of the 2025 Health and Social Care (HASC) pilot project conducted by the Healthcare Team. The primary objective of the project was to evaluate the services available for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long Covid.”
PDF | Thread
UK Action for ME Big Survey 2025 closing soon
The survey can be completed until the end of Tuesday 27 January 2026
"Every 5 years, we develop our Big Survey. It enables us to gather large amounts of data which can then be analysed and used to support our wider work and illustrate the impact of ME."
Website | Thread
UK IPIC Annual Conference 2026
The International Post Covid & Post Infection Conditions Society conference will be taking place on 25th March in Nottingham. Details of the sessions are pending.
“Note: This event is restricted to healthcare professionals and academics working within the field of Post Infection Conditions or with an interest in the field of Post Infection Conditions.”
This event is organised by the British Society of Physical and Rehabilitation Medicine.
Website | Thread
Medscape Multiple Abnormal Responses to Exertion Seen in ME/CFS
Article by Miriam E. Tucker about the recent plasma profiling study on PEM by Germain, Hanson et al. Includes comments from Calabrese and co-author Glass who says: “Fundamentally, the ME/CFS patient’s response to exercise is very different and very impaired….These are objective changes in the bodies of these patients that correspond with what the patients are saying."
Article l Thread
Medscape News Canada Healthcare Workers With Long COVID Struggle to Find Support and Care in an Environment of Denial
The article discusses barriers faced by healthcare workers with Long Covid including denial, stigma, and doctors who lack education and training.
Article | Thread
..........
Coming events
Bateman Horne Center – "Coffee" with a Clinician
Wednesday, January 14, 10 am MDT (9 am PT / 11 am CT / 12 pm ET)
Topic: Basics of Long COVID, ME/CFS, & Comorbidities
Free to attend, optional $5 donation.
Registration | Thread
Bateman Horne Center – Free Online Support Group
Tuesday, January 20, 1 - 2 PM MDT
Topic: Navigating Loneliness and Rebuilding Connection
Advance registration required, registration link shows time in your time zone.
Registration | Thread
..........
Research news and commentary
Solve ME - What's New in ME/CFS? Interview with Dr. Roshan Kumar
Dr. Roshan Kumar discusses his research on T-cell dysfunction in ME/CFS and Long COVID.
Summary | Video | Thread
..........
Research
ME/CFS research
Multi-omics identifies lipid accumulation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cell lines: a case-control study — Missailidis et al.
"These cellular accumulations are a novel observation broadly aligning with similar accumulations in biofluids, greatly strengthening a consistent evidence base for abnormal lipid handling in ME/CFS."
Article | Thread
Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome — Martini Sasso et al.
"We identified a significant reduction in TRPM3 ion channel function in NK cells isolated from ME/CFS patients, both in response to stimulation with the agonist PregS (p < 0.0001) and in suppression of activation using ononetin (p < 0.0001)."
Article | Thread
Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome: Phenotypes, Severity, and Biomarkers — Purpura et al.
"revealed an elevation of cytokines and histamine across all groups, consistent with immune dysregulation and possible mast cell activation. CRP, a commonly used clinical screening test for inflammation, was normal in most patients" "Among PASC patients, only 14% reported worsening of their symptoms after vaccination, while 6.5% reported improvement."
Article | Thread
Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system — Nunes et al.
Hypothesis paper. "Confirming the details of the mechanisms proposed here in vivo will require the detection and quantification of cell-specific senescence (e.g., endothelial senescence) in patients, and these are still being developed."
Article | Thread
Evaluating working memory functioning in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review and meta-analysis — Maddison Penson and Kate Kelly
"These findings contribute to the body of ME/CFS research by articulating where specific working memory deficits lie. Specifically, they show that individuals with ME/CFS have impaired verbal memory performance."
Article | Thread
Long Covid research
Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism — Daniel D. Carroll et al.
"Here, we demonstrate that antigen-specific memory T cells from post-COVID individuals show lower glycolysis usage and disordered mitochondrial metabolism in response to commonly encountered childhood and environmental pathogens."
Preprint | Thread
Exhaled breath-based clusters in children with post-COVID condition — Shahriyar Shahbazi Khamas et al.
Compared to Cluster 1 (n=38), Cluster 2 (n=16) consisted predominantly of older girls (69%) with a median age of 16 years and exhibited more severe PPCC-related outcomes, including higher PROMIS fatigue scores. Six volatile organic compounds (VOCs) were identified as biomarkers that effectively differentiated the two clusters." "These VOCs, previously reported in the literature, highlight metabolic and inflammatory disruptions and demonstrated high discriminatory performance "
Article | Thread
Choroid plexus alterations in long COVID and their associations with IL-6 — Cao et al.
"ChP volume changes between baseline and one-year follow-up suggested differing recovery and neuroinflammatory patterns, with long COVID linked to ongoing ChP volume reduction trends, COVID-19 survivors showing recovery-related increases, and previously healthy individuals who progressed to COVID-19 survivors demonstrated new vulnerabilities in ChP volume."
Article | Thread
Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection — Verma et al.
"we showed that ameliorating the inflammatory response with corticosteroids in conjunction with antiviral therapy soon after infection, is effective in diminishing neurological PASC in mice, while neither modality by itself is as effective."
Article | Thread
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset — Yang et al.
"The fact that average elevation in pTau-181 grew over the observational period may, if replicated longitudinally, suggest a temporal lag between COVID-19 onset and increases in circulating levels of tau phosphorylation."
Article | Thread
Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series — Pridgen and Putrino
Open label pilot study. "The results of this case series suggest a potential synergy between IMC-2 and Paxlovid, as indicated by an apparent improvement in antiviral performance with the combination compared to IMC-2 alone"
Article | Thread
Social Determinants of Health and Pediatric Long COVID in the US — Kyung E. Rhee et al.
RECOVER study. "The results of this study demonstrate that long COVID is more prevalent among children living with economic instability and adverse social and community contexts. Given their young age and unclear trajectory of symptoms over the life course, the long-term economic effects and the health care needs of this population may be immense."
Article | Thread
Economic Burden of Long COVID: Lost Labor Costs in US Adults — Rachel Liu-Galvin et al.
"In the study population, the weighted prevalence of LC was 7.8%" "The present results indicate the real-world cost of LC on lost labor far exceeds this, amounting to more than $12 billion in 2022 alone based on the population-level estimate."
Article | Thread
Excess primary healthcare consultations in Norway in 2024 compared to pre-COVID-19-pandemic baseline trends — White et al.
"Substantial increases were observed in primary healthcare consultations in 2024 compared to prepandemic levels. Many of the conditions with the greatest excess are associated with post-acute COVID-19 sequelae"
Article | Thread
Comparison of Healthcare Expenditures Among Individuals With and Without Long COVID in the United States — Emeka Elvis Duru et al.
"Long COVID imposes a substantial financial burden on individuals and healthcare systems, primarily through increased outpatient and office-based service utilization."
Article | Thread
...........
S4ME social media: Forum, Mastodon, Bluesky
News, advocacy and articles
UK ME Association Healthcare Team releases their annual report for 2025
“This report presents the findings of the 2025 Health and Social Care (HASC) pilot project conducted by the Healthcare Team. The primary objective of the project was to evaluate the services available for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long Covid.”
PDF | Thread
UK Action for ME Big Survey 2025 closing soon
The survey can be completed until the end of Tuesday 27 January 2026
"Every 5 years, we develop our Big Survey. It enables us to gather large amounts of data which can then be analysed and used to support our wider work and illustrate the impact of ME."
Website | Thread
UK IPIC Annual Conference 2026
The International Post Covid & Post Infection Conditions Society conference will be taking place on 25th March in Nottingham. Details of the sessions are pending.
“Note: This event is restricted to healthcare professionals and academics working within the field of Post Infection Conditions or with an interest in the field of Post Infection Conditions.”
This event is organised by the British Society of Physical and Rehabilitation Medicine.
Website | Thread
Medscape Multiple Abnormal Responses to Exertion Seen in ME/CFS
Article by Miriam E. Tucker about the recent plasma profiling study on PEM by Germain, Hanson et al. Includes comments from Calabrese and co-author Glass who says: “Fundamentally, the ME/CFS patient’s response to exercise is very different and very impaired….These are objective changes in the bodies of these patients that correspond with what the patients are saying."
Article l Thread
Medscape News Canada Healthcare Workers With Long COVID Struggle to Find Support and Care in an Environment of Denial
The article discusses barriers faced by healthcare workers with Long Covid including denial, stigma, and doctors who lack education and training.
Article | Thread
..........
Coming events
Bateman Horne Center – "Coffee" with a Clinician
Wednesday, January 14, 10 am MDT (9 am PT / 11 am CT / 12 pm ET)
Topic: Basics of Long COVID, ME/CFS, & Comorbidities
Free to attend, optional $5 donation.
Registration | Thread
Bateman Horne Center – Free Online Support Group
Tuesday, January 20, 1 - 2 PM MDT
Topic: Navigating Loneliness and Rebuilding Connection
Advance registration required, registration link shows time in your time zone.
Registration | Thread
..........
Research news and commentary
Solve ME - What's New in ME/CFS? Interview with Dr. Roshan Kumar
Dr. Roshan Kumar discusses his research on T-cell dysfunction in ME/CFS and Long COVID.
Summary | Video | Thread
..........
Research
ME/CFS research
Multi-omics identifies lipid accumulation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cell lines: a case-control study — Missailidis et al.
"These cellular accumulations are a novel observation broadly aligning with similar accumulations in biofluids, greatly strengthening a consistent evidence base for abnormal lipid handling in ME/CFS."
Article | Thread
Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome — Martini Sasso et al.
"We identified a significant reduction in TRPM3 ion channel function in NK cells isolated from ME/CFS patients, both in response to stimulation with the agonist PregS (p < 0.0001) and in suppression of activation using ononetin (p < 0.0001)."
Article | Thread
Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome: Phenotypes, Severity, and Biomarkers — Purpura et al.
"revealed an elevation of cytokines and histamine across all groups, consistent with immune dysregulation and possible mast cell activation. CRP, a commonly used clinical screening test for inflammation, was normal in most patients" "Among PASC patients, only 14% reported worsening of their symptoms after vaccination, while 6.5% reported improvement."
Article | Thread
Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system — Nunes et al.
Hypothesis paper. "Confirming the details of the mechanisms proposed here in vivo will require the detection and quantification of cell-specific senescence (e.g., endothelial senescence) in patients, and these are still being developed."
Article | Thread
Evaluating working memory functioning in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review and meta-analysis — Maddison Penson and Kate Kelly
"These findings contribute to the body of ME/CFS research by articulating where specific working memory deficits lie. Specifically, they show that individuals with ME/CFS have impaired verbal memory performance."
Article | Thread
Long Covid research
Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism — Daniel D. Carroll et al.
"Here, we demonstrate that antigen-specific memory T cells from post-COVID individuals show lower glycolysis usage and disordered mitochondrial metabolism in response to commonly encountered childhood and environmental pathogens."
Preprint | Thread
Exhaled breath-based clusters in children with post-COVID condition — Shahriyar Shahbazi Khamas et al.
Compared to Cluster 1 (n=38), Cluster 2 (n=16) consisted predominantly of older girls (69%) with a median age of 16 years and exhibited more severe PPCC-related outcomes, including higher PROMIS fatigue scores. Six volatile organic compounds (VOCs) were identified as biomarkers that effectively differentiated the two clusters." "These VOCs, previously reported in the literature, highlight metabolic and inflammatory disruptions and demonstrated high discriminatory performance "
Article | Thread
Choroid plexus alterations in long COVID and their associations with IL-6 — Cao et al.
"ChP volume changes between baseline and one-year follow-up suggested differing recovery and neuroinflammatory patterns, with long COVID linked to ongoing ChP volume reduction trends, COVID-19 survivors showing recovery-related increases, and previously healthy individuals who progressed to COVID-19 survivors demonstrated new vulnerabilities in ChP volume."
Article | Thread
Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection — Verma et al.
"we showed that ameliorating the inflammatory response with corticosteroids in conjunction with antiviral therapy soon after infection, is effective in diminishing neurological PASC in mice, while neither modality by itself is as effective."
Article | Thread
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset — Yang et al.
"The fact that average elevation in pTau-181 grew over the observational period may, if replicated longitudinally, suggest a temporal lag between COVID-19 onset and increases in circulating levels of tau phosphorylation."
Article | Thread
Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series — Pridgen and Putrino
Open label pilot study. "The results of this case series suggest a potential synergy between IMC-2 and Paxlovid, as indicated by an apparent improvement in antiviral performance with the combination compared to IMC-2 alone"
Article | Thread
Social Determinants of Health and Pediatric Long COVID in the US — Kyung E. Rhee et al.
RECOVER study. "The results of this study demonstrate that long COVID is more prevalent among children living with economic instability and adverse social and community contexts. Given their young age and unclear trajectory of symptoms over the life course, the long-term economic effects and the health care needs of this population may be immense."
Article | Thread
Economic Burden of Long COVID: Lost Labor Costs in US Adults — Rachel Liu-Galvin et al.
"In the study population, the weighted prevalence of LC was 7.8%" "The present results indicate the real-world cost of LC on lost labor far exceeds this, amounting to more than $12 billion in 2022 alone based on the population-level estimate."
Article | Thread
Excess primary healthcare consultations in Norway in 2024 compared to pre-COVID-19-pandemic baseline trends — White et al.
"Substantial increases were observed in primary healthcare consultations in 2024 compared to prepandemic levels. Many of the conditions with the greatest excess are associated with post-acute COVID-19 sequelae"
Article | Thread
Comparison of Healthcare Expenditures Among Individuals With and Without Long COVID in the United States — Emeka Elvis Duru et al.
"Long COVID imposes a substantial financial burden on individuals and healthcare systems, primarily through increased outpatient and office-based service utilization."
Article | Thread
...........
S4ME social media: Forum, Mastodon, Bluesky
Week beginning 12th January 2026
News, advocacy and articles
UK Action for ME have released an Impact Statement template
“This new resource, developed by our Adults Advocacy Service in collaboration with their steering group, aims to support people with ME to communicate how ME impacts them and what adjustments would best support them.”
Template | Thread
The Sick Times "Severe people may hold answers to Long COVID. They must be included in research."
This article argues that research studies which include severe cases "may reveal what drives the disease at its core, mechanisms that remain invisible in milder cases." It also lists examples of research studies that have included severe cases to demonstrate that it is possible.
Article | Thread
Anil van der Zee “Are Dutch psychologists distancing themselves from graded activity in ME/CFS?”
ME/CFS blogger and advocate Anil writes about an article from two Dutch clinical psychologists, Klaas Huijbregts and Luuk Stroink, who critiqued the rigid application of CBT for ME/CFS and its focus on graded activity. While Anil sees this as a positive development, he also highlights some remaining problems with their approach.
Blog | Thread
Denmark Brian Heron has written a good comment in a journal on health and politics, Sundhedspolitisk Tidsskrift. He criticises Center for Functional Disorders for confusing legitimate criticism with extreme behaviour. This is stigmatising and has consequences for how patients and carers are perceived.
Article l Thread
Norway The nursing journal has interviewed the new general secretary of the Norwegian ME Association, Grethe Reinhardtsen. She has background as a nurse and from politics. She wants more investment in medical research into ME and for the illness to get recognised and better understood.
Article l Thread
BJGP Life Book review: Psychology's Quiet Conservatism: How a Supposedly Woke Science Promotes Capitalism and Protect Privilege
A positive review by Elke Hausmann of professor Brian Hughes' latest book. "Anyone who has read any of my previous articles will know that I am engaged with the discussions around long COVID and myalgic encephalomyelitis, and part three of this book addresses those topics, among references to other medical conditions. This section deals with ‘the psychologising of the sick’ (beyond the chapter with that title), and any GP who isn’t aware that our treasured ‘biopsychosocial’ approach to patients is not universally seen as positive by everyone (and with good reason), will find a lot of background information as to why that is the case."
Article l Thread
FAIR "Media Baffled by Wheelchair ‘Miracles’ Because They Don’t Understand Disability"
Article about ambulatory wheelchair users, a response to a Wall Street Journal article that claimed people are pretending to need wheelchairs.
Mentions Long Covid, ME/CFS, and several other medical conditions as possible reasons for needing a wheelchair.
Article | Thread
New York State (USA) has proclaimed May 2026 as "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Awareness Month in the State of New York."
Proclamation | Thread
.........
Coming events
Solve ME Webinar – Protecting the Ones You Love: Legal & Insurance Tools for ME/CFS Caregivers
Wednesday, February 11, 12 - 1 PM Pacific / 3 - 4 PM Eastern
Discussion of "long-term disability (LTD) insurance, long-term care (LTC) planning, medical and legal documentation tips, and practical steps families can take to secure benefits and long-term stability."
Announcement | Registration | Thread
........
Research news and commentary
ICanCME Research Network has posted a recording from their November 4-6 webinar ("Nothing About Us Without Us") on their YouTube channel.
Video | Thread
Solve ME has posted a recording from their Jan 15 webinar (“From Mystery to Measurable: The Science Behind the New ME/CFS Blood Test”) on their YouTube channel.
Video | Thread
........
Research
ME/CFS research
A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID — Thomas et al.
"The strength of the MELLOW study lies in its unique study design and the advanced techniques employed for biological measurement, particularly with regards to hormones." "By repeated sample collection at standardised times, the study captures symptom fluctuations while accounting for diurnal and menstrual cycle dynamics."
Article | Thread
Immunosenescence-Driven Hemodynamic Dysregulation and Cognitive Impairment in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Integrative Perspective — Huimin Xu et al.
"The review proposes an “immune–vascular–cognitive axis” linking peripheral immune aging to central neural dysfunction."
Article | Thread
Long Covid research
Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy — Weber-Fahr et al.
"Our 31P MRSI findings provide robust in vivo evidence for impaired cellular energy metabolism in the brains of patients with PCCo." "lower ATP/PCr ratios in the ACC correlated with poorer performance on neurocognitive tests, suggesting a direct link between metabolic dysfunction in this key brain region and cognitive impairment in PCCo patients."
Article | Thread
Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome — Martins et al.
"this study demonstrates that PCS is associated with regionally specific alterations in cerebral perfusion and oxygen metabolism. These findings support a dual process model in which hippocampal hypermetabolism seems to reflect compensatory adaptation, while ACC neurovascular uncoupling might derive from neuroimmune disruption." "findings identify the ACC as a metabolically vulnerable hub in PCS"
Preprint | Thread
EEG-based frontal excitation/inhibition balance as an objective biomarker for cognitive fatigue across multiple sclerosis and Long COVID — Linnhoff et al.
"findings demonstrate that the frontal aperiodic exponent is a robust, regionally specific, and clinically relevant correlate of cognitive fatigue across neurological and post-viral conditions." "this study provides evidence for a transdiagnostic mechanism underlying fatigue, independent of disease etiology."
Article | Thread
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19 — Tsai-Ling Liao et al.
"Human neutrophils incubated with EVs from patients with moderate to severe COVID-19 or long COVID exhibited increased [lipid droplet] accumulation, accompanied by elevated ROS production and NET DNA release (p < 0.05)." "These effects were absent in neutrophils exposed to EVs from healthy controls."
Article | Thread
Autonomic small fiber involvement in painful long COVID: a histological and clinical study — Falco et al.
"we observed histological evidence of postganglionic sympathetic fibers damage in dermal structures even in patients with normal [intraepidermal nerve fibre density], indicating that autonomic involvement can occur independently of [small fibre neuropathy]."
Article | Thread
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID — Kumar et al.
"We also defined a distinct circulating CD14⁺ monocyte state (LC-Mo) associated with LC […] showed increased TGFβ/WNT–β-catenin signaling that increased over time and exhibited interindividual variability."
Article | Thread
Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone — Otsuka et al.
"Although the peak responses were preserved across the axes, we observed consistent patterns of delayed peaks and sustained elevation at 120 min, especially in the responses of gonadotropins, PRL, and TSH." "the peak ACTH and cortisol responses to CRH and their recovery levels at 120 min were nearly normal, failing to detect clear HPA axis abnormalities."
Article | Thread
Rethinking measurement of health outcomes in Long COVID: complexities, challenges and considerations — Bhéreur et al.
"This dynamic aspect of the condition adds to the complexity of timing and interpreting outcome measures." "symptoms and performance may be very different on an “average” day from those during PEM/PESE or flare-up state." "Furthermore, PEM/PESE onset can be delayed by hours or days after the trigger, further complexifying appropriate capture."
Article | Thread
Is long-term disruption of the renin-angiotensin-aldosterone system associated with long COVID? A retrospective cohort study among healthcare workers — Lange-Tal et al.
"findings do not support the hypothesis that differences in the soluble levels of RAAS components contribute to the development of LC within the time points measured in this study." "small sample sizes and highly unstable biomarkers limit statistical power."
Article | Thread
Trajectory, healthcare utilisation and recovery in 3590 individuals with long covid: a 4-year prospective cohort analysis — Jai Prashar et al.
"Recovery rates were low with significant healthcare utilisation, both within and outside the LC service."
Article | Thread
...........
S4ME social media: Forum, Mastodon, Bluesky
News, advocacy and articles
UK Action for ME have released an Impact Statement template
“This new resource, developed by our Adults Advocacy Service in collaboration with their steering group, aims to support people with ME to communicate how ME impacts them and what adjustments would best support them.”
Template | Thread
The Sick Times "Severe people may hold answers to Long COVID. They must be included in research."
This article argues that research studies which include severe cases "may reveal what drives the disease at its core, mechanisms that remain invisible in milder cases." It also lists examples of research studies that have included severe cases to demonstrate that it is possible.
Article | Thread
Anil van der Zee “Are Dutch psychologists distancing themselves from graded activity in ME/CFS?”
ME/CFS blogger and advocate Anil writes about an article from two Dutch clinical psychologists, Klaas Huijbregts and Luuk Stroink, who critiqued the rigid application of CBT for ME/CFS and its focus on graded activity. While Anil sees this as a positive development, he also highlights some remaining problems with their approach.
Blog | Thread
Denmark Brian Heron has written a good comment in a journal on health and politics, Sundhedspolitisk Tidsskrift. He criticises Center for Functional Disorders for confusing legitimate criticism with extreme behaviour. This is stigmatising and has consequences for how patients and carers are perceived.
Article l Thread
Norway The nursing journal has interviewed the new general secretary of the Norwegian ME Association, Grethe Reinhardtsen. She has background as a nurse and from politics. She wants more investment in medical research into ME and for the illness to get recognised and better understood.
Article l Thread
BJGP Life Book review: Psychology's Quiet Conservatism: How a Supposedly Woke Science Promotes Capitalism and Protect Privilege
A positive review by Elke Hausmann of professor Brian Hughes' latest book. "Anyone who has read any of my previous articles will know that I am engaged with the discussions around long COVID and myalgic encephalomyelitis, and part three of this book addresses those topics, among references to other medical conditions. This section deals with ‘the psychologising of the sick’ (beyond the chapter with that title), and any GP who isn’t aware that our treasured ‘biopsychosocial’ approach to patients is not universally seen as positive by everyone (and with good reason), will find a lot of background information as to why that is the case."
Article l Thread
FAIR "Media Baffled by Wheelchair ‘Miracles’ Because They Don’t Understand Disability"
Article about ambulatory wheelchair users, a response to a Wall Street Journal article that claimed people are pretending to need wheelchairs.
Mentions Long Covid, ME/CFS, and several other medical conditions as possible reasons for needing a wheelchair.
Article | Thread
New York State (USA) has proclaimed May 2026 as "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Awareness Month in the State of New York."
Proclamation | Thread
.........
Coming events
Solve ME Webinar – Protecting the Ones You Love: Legal & Insurance Tools for ME/CFS Caregivers
Wednesday, February 11, 12 - 1 PM Pacific / 3 - 4 PM Eastern
Discussion of "long-term disability (LTD) insurance, long-term care (LTC) planning, medical and legal documentation tips, and practical steps families can take to secure benefits and long-term stability."
Announcement | Registration | Thread
........
Research news and commentary
ICanCME Research Network has posted a recording from their November 4-6 webinar ("Nothing About Us Without Us") on their YouTube channel.
Video | Thread
Solve ME has posted a recording from their Jan 15 webinar (“From Mystery to Measurable: The Science Behind the New ME/CFS Blood Test”) on their YouTube channel.
Video | Thread
........
Research
ME/CFS research
A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID — Thomas et al.
"The strength of the MELLOW study lies in its unique study design and the advanced techniques employed for biological measurement, particularly with regards to hormones." "By repeated sample collection at standardised times, the study captures symptom fluctuations while accounting for diurnal and menstrual cycle dynamics."
Article | Thread
Immunosenescence-Driven Hemodynamic Dysregulation and Cognitive Impairment in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Integrative Perspective — Huimin Xu et al.
"The review proposes an “immune–vascular–cognitive axis” linking peripheral immune aging to central neural dysfunction."
Article | Thread
Long Covid research
Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy — Weber-Fahr et al.
"Our 31P MRSI findings provide robust in vivo evidence for impaired cellular energy metabolism in the brains of patients with PCCo." "lower ATP/PCr ratios in the ACC correlated with poorer performance on neurocognitive tests, suggesting a direct link between metabolic dysfunction in this key brain region and cognitive impairment in PCCo patients."
Article | Thread
Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome — Martins et al.
"this study demonstrates that PCS is associated with regionally specific alterations in cerebral perfusion and oxygen metabolism. These findings support a dual process model in which hippocampal hypermetabolism seems to reflect compensatory adaptation, while ACC neurovascular uncoupling might derive from neuroimmune disruption." "findings identify the ACC as a metabolically vulnerable hub in PCS"
Preprint | Thread
EEG-based frontal excitation/inhibition balance as an objective biomarker for cognitive fatigue across multiple sclerosis and Long COVID — Linnhoff et al.
"findings demonstrate that the frontal aperiodic exponent is a robust, regionally specific, and clinically relevant correlate of cognitive fatigue across neurological and post-viral conditions." "this study provides evidence for a transdiagnostic mechanism underlying fatigue, independent of disease etiology."
Article | Thread
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19 — Tsai-Ling Liao et al.
"Human neutrophils incubated with EVs from patients with moderate to severe COVID-19 or long COVID exhibited increased [lipid droplet] accumulation, accompanied by elevated ROS production and NET DNA release (p < 0.05)." "These effects were absent in neutrophils exposed to EVs from healthy controls."
Article | Thread
Autonomic small fiber involvement in painful long COVID: a histological and clinical study — Falco et al.
"we observed histological evidence of postganglionic sympathetic fibers damage in dermal structures even in patients with normal [intraepidermal nerve fibre density], indicating that autonomic involvement can occur independently of [small fibre neuropathy]."
Article | Thread
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID — Kumar et al.
"We also defined a distinct circulating CD14⁺ monocyte state (LC-Mo) associated with LC […] showed increased TGFβ/WNT–β-catenin signaling that increased over time and exhibited interindividual variability."
Article | Thread
Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone — Otsuka et al.
"Although the peak responses were preserved across the axes, we observed consistent patterns of delayed peaks and sustained elevation at 120 min, especially in the responses of gonadotropins, PRL, and TSH." "the peak ACTH and cortisol responses to CRH and their recovery levels at 120 min were nearly normal, failing to detect clear HPA axis abnormalities."
Article | Thread
Rethinking measurement of health outcomes in Long COVID: complexities, challenges and considerations — Bhéreur et al.
"This dynamic aspect of the condition adds to the complexity of timing and interpreting outcome measures." "symptoms and performance may be very different on an “average” day from those during PEM/PESE or flare-up state." "Furthermore, PEM/PESE onset can be delayed by hours or days after the trigger, further complexifying appropriate capture."
Article | Thread
Is long-term disruption of the renin-angiotensin-aldosterone system associated with long COVID? A retrospective cohort study among healthcare workers — Lange-Tal et al.
"findings do not support the hypothesis that differences in the soluble levels of RAAS components contribute to the development of LC within the time points measured in this study." "small sample sizes and highly unstable biomarkers limit statistical power."
Article | Thread
Trajectory, healthcare utilisation and recovery in 3590 individuals with long covid: a 4-year prospective cohort analysis — Jai Prashar et al.
"Recovery rates were low with significant healthcare utilisation, both within and outside the LC service."
Article | Thread
...........
S4ME social media: Forum, Mastodon, Bluesky