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I think analyzing the whole genome of severe ME patients to fish for rare genetic illnesses that can cause ME is a worthwhile thing to do. It's the inverse approach to GWAS. As far as I know not a single case of ME had the cause identified this way - however with other illnesses it certainly did happen. If you look at dementia patients, autism, parkinson's, there is always a small group with rare mutations causing it. I don't see why it shouldn't be the same for ME. I wonder who the world leaders are when it comes to this.