Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants 2024 Marshall-Gradisnik

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Am afraid this landmark study featured in the Times article is just the pilot study discussed here
https://twitter.com/user/status/1813859929348010042

 

Maybe not landmark, but once again a curious concept, this one of acquired channelopathy, in that in many ways it fits into several contested diseases' sequelae - including ME/CFS and Gulf War.

You'd think large scale replication efforts would have already been done, or at least attempted. Maybe they have and I've simply forgotten. If not, time to get on with it?

The implications of "acquired" are what continue to fascinate me. Is there a genetic component that's triggered artificially? Is there a viral agent that's introduced and somehow persists?

Of course, cool theories are a dime a dozen in our world. They're a dime a dozen in BPS literature as well - or at least, a dime a dozen variations of a single repetitive talking point.

We need to distinguish our work from their's with science that is both unambiguous and unassailable. That's dicey when dealing with subject matter with so little substantive and trustworthy precedent.

 

I think you might find that these two are frequently put together.........

 

Work was done in the US claiming that sarin gas exposure in genetically prone individuals was at the root of the problem. I don't know about the quality of the work or how it fits with Times study.

UTSW genetic study confirms sarin nerve gas as cause of Gulf War illness: Newsroom - UT Southwestern, Dallas, Texas

 

Noticed that this researcher: Douglas C Youvan has written a comment/editorial on the finding. Maybe it will be published somewhere in the future? Perhaps also the reason why the study was featured in The Times?

https://www.researchgate.net/public...nnel_Dysfunction_Offers_New_Hope_for_Veterans