Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium, 2012

[Hoopoe]

The overall association between common gene variants in BP loci and OH was generally weak and the direction of effect inconsistent with resting BP findings. These results suggest that OH and resting BP share few genetic components.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442958/

 

[Hoopoe]

One of the SNPs more strongly associated with orthostatic hypotension in this study is a gene that plays a role in B cells and is exploited by the Epstein-Barr virus. The mechanism by which this SNP causes orthostatic hypotension could be autoimmunity. The gene is also associated with lymphoma. One of the interesting bits about this paper. Although in the end the effect of these SNPs is weak. I hope I didn't get anything wrong here as I wrote from memory.