Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat (2020) Alexander et al.

leokitten · Oct 26, 2020

https://www.nature.com/articles/s41467-020-19167-0

Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25) has been implicated in these illnesses, it is unknown whether this over-activity is causal. By combining targeted intracerebral microinfusions with cardiovascular and behavioral monitoring in marmosets, we show that over-activation of sgACC/25 reduces vagal tone and heart rate variability, alters cortisol dynamics during stress and heightens reactivity to proximal and distal threat. 18F-FDG PET imaging shows these changes are accompanied by altered activity within a network of brain regions including the amygdala, hypothalamus and dorsolateral prefrontal cortex. Ketamine, shown to have rapid antidepressant effects, fails to reverse elevated arousal to distal threat contrary to the beneficial effects we have previously demonstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its actions.
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Summary news piece by University of Cambridge:
Marmoset study finds single brain region linking depression and anxiety, heart disease, and people’s sensitivity to treatment

leokitten · Oct 26, 2020

Isn’t the anterior cingulate cortex one is the brain regions implicated in neurological disorders like ME?

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Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat (2020) Alexander et al.

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Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat (2020) Alexander et al.

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