depression

Association of Comorbid and Incident Depression and Other Mental Health Conditions With Long-COVID: Results From the Johns Hopkins COVID Long Study Long-term complications following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as long-COVID, present significant...

Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients Major depressive disorder (MDD) involves both central nervous system dysfunction and systemic immune alterations. Using a systems biology approach, we investigated whether...

The role of genetic liability for psychiatric disorders and personality traits in post covid syndrome: data from three Nordic population cohorts BACKGROUND Post-COVID syndrome (PCS) remains a substantial public health concern, yet its genetic determinants are poorly understood. Psychiatric...

Disentangling Fatigue from Depression among Survivors of Severe COVID-19 PURPOSE Survivors of severe COVID-19 commonly experience post-intensive care syndrome (PICS), which includes depression and fatigue. Fatigue is far more common and may inflate depression severity given overlapping...

Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity Chronic stress can trigger major depressive disorder through peripheral immune factors. Enhanced circulating levels of complement component 3 (C3), a key...

Chronic insomnia remitting after maxillomandibular advancement for mild obstructive sleep apnea: a case series Michael Proothi, Victor J R Grazina, Avram R Gold https://pmc.ncbi.nlm.nih.gov/articles/PMC6693215/ (PDF available) Background: Chronic insomnia and obstructive sleep apnea are both...

Phenotypic overlap of mental health impairment in post-COVID condition and depressive disorders: Insights from the DigiHero cohort BACKGROUND Post-COVID condition (PCC) has been linked to substantial mental health impairment. However, a comprehensive and dimensional understanding of the...

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy Abstract Cytokine effects on behavior may be related to alterations in glutamate metabolism. We therefore measured glutamate concentrations in brain regions shown to be affected by...

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions Abstract Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. We report results of a large meta-analysis...

Use and Perceived Helpfulness of Different Intervention Strategies in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Depression BACKGROUND Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or depression both frequently report debilitating exhaustion, yet the two...

Neurological sequela of COVID-19 in adults with multiple sclerosis BACKGROUND Possible interactions in neuropsychiatric presentations of multiple sclerosis (MS) and COVID-19 may occur, which has been proposed in previous, albeit limited, literature. OBJECTIVES Examine COVID-19 disease...

Mapping the genetic landscape across 14 psychiatric disorders Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar...

Depression is a common psychiatric disorder, and increasing evidence implicates the dysregulation of extracellular ATP and hippocampal dysfunction in its pathophysiology. However, whether ATP release is involved in depression and mechanisms underlying this involvement remain unclear. Moreover...

Depression as a moderator and mediator of functional status in patients with Long COVID: a cross-sectional and longitudinal observational study from the PERCEIVE cohort in Australia BACKGROUND In patients with post-acute sequelae of COVID-19 (PASC), depression has been associated with symptom...

Exploring predictors of post-COVID-19 condition among 810 851 individuals in Sweden BACKGROUND Long-term effects of COVID-19 can place burden on individuals, healthcare, and society. We aimed to evaluate the importance of a wide range of potential risk factors for being diagnosed with...

Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19 IMPORTANCE Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of...

Fatigue, cognitive complaints, dyspnea, anxiety, and depression as post-COVID syndrome: a cross-sectional study in Sfax, Southern Tunisia INTRODUCTION post-COVID refers to symptoms and health problems that continue or develop after the initial phase of a COVID-19 infection has resolved. It...

Genome-wide association study of adolescent-onset depression Abstract Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide...

Associations of selective serotonin reuptake inhibitors and long COVID risk in patients with depression: a retrospective cohort study PURPOSE To evaluate the potential of selective serotonin reuptake inhibitors (SSRIs) in reducing the risk of long COVID in patients with depression. METHODS...

Large responses to antidepressants or methodological artifacts? A secondary analysis of STAR∗D, a single-arm, open-label, nonindustry antidepressant trial https://www.sciencedirect.com/science/article/pii/S0895435625002768 Objectives To replicate Stone et al's (2022) finding that the...