depression

Longitudinal Study of Anxiety and Depression During COVID-19 Lockdown: A Secondary Data Analysis Abstract The COVID-19 pandemic has significantly disrupted the everyday lives of people around the world, with countries announcing lockdowns aiming to reduce the spread of the virus. This...

Anxiety-Depressive Disorders in 200 Patients with Post-COVID-19 Syndrome: Prevalence and Predictors from a Cross-Sectional Study Abstract Background and Objectives: Recovering from COVID-19 does not always imply a full return to health and may lead to the development of post-COVID-19...

The role of disease history score in the association between depression history and current ME/CFS among US adults Mao, Song; Wu, Liangxia Objective To explore the role of disease history score in the association between depression history and current myalgic encephalomyelitis/chronic fatigue...

Post-Acute Sequelae of COVID-19 Across 15 Major Health Domains and 67 Diseases in Individuals With Depressive Disorder: A Korean Nationwide Cohort Study Abstract Background Individuals with depressive disorder often face barriers in accessing healthcare; however, research on the acute and...

Cerebral gray matter volumes in long-term post-COVID patients are associated with peripheral kynurenine pathway metabolites and the severity of depressive symptoms BACKGROUND Structural brain changes and immune-metabolic alterations are widely reported in post-COVID condition (PCC)...

Donepezil ameliorates fatigue and depression in PASC patients with HHV-6B SITH-1-induced acetylcholine deficiency Abstract Introduction: The pathogenesis of post-acute sequelae of SARS-CoV-2 infection (PASC) remains poorly understood, and no effective treatment has been established...

Abstract: Background. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and irritable bowel syndrome (IBS) frequently co-occur following infection, yet shared genetic architecture at the locus level has not been systematically characterised. Aims. To estimate global and local genetic...

Association of Comorbid and Incident Depression and Other Mental Health Conditions With Long-COVID: Results From the Johns Hopkins COVID Long Study Long-term complications following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as long-COVID, present significant...

Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients Major depressive disorder (MDD) involves both central nervous system dysfunction and systemic immune alterations. Using a systems biology approach, we investigated whether...

The role of genetic liability for psychiatric disorders and personality traits in post covid syndrome: data from three Nordic population cohorts BACKGROUND Post-COVID syndrome (PCS) remains a substantial public health concern, yet its genetic determinants are poorly understood. Psychiatric...

Disentangling Fatigue from Depression among Survivors of Severe COVID-19 PURPOSE Survivors of severe COVID-19 commonly experience post-intensive care syndrome (PICS), which includes depression and fatigue. Fatigue is far more common and may inflate depression severity given overlapping...

Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity Chronic stress can trigger major depressive disorder through peripheral immune factors. Enhanced circulating levels of complement component 3 (C3), a key...

Chronic insomnia remitting after maxillomandibular advancement for mild obstructive sleep apnea: a case series Michael Proothi, Victor J R Grazina, Avram R Gold https://pmc.ncbi.nlm.nih.gov/articles/PMC6693215/ (PDF available) Background: Chronic insomnia and obstructive sleep apnea are both...

Phenotypic overlap of mental health impairment in post-COVID condition and depressive disorders: Insights from the DigiHero cohort BACKGROUND Post-COVID condition (PCC) has been linked to substantial mental health impairment. However, a comprehensive and dimensional understanding of the...

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy Abstract Cytokine effects on behavior may be related to alterations in glutamate metabolism. We therefore measured glutamate concentrations in brain regions shown to be affected by...

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions Abstract Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. We report results of a large meta-analysis...

Use and Perceived Helpfulness of Different Intervention Strategies in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Depression BACKGROUND Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or depression both frequently report debilitating exhaustion, yet the two...

Neurological sequela of COVID-19 in adults with multiple sclerosis BACKGROUND Possible interactions in neuropsychiatric presentations of multiple sclerosis (MS) and COVID-19 may occur, which has been proposed in previous, albeit limited, literature. OBJECTIVES Examine COVID-19 disease...

Abstract Rationale: Depression is a common cause of morbidity and mortality worldwide. Depression is often treated with antidepressants or psychological therapy, or both, but some people may prefer alternative approaches such as exercise. This review updates one first published in 2008 and last...

Mapping the genetic landscape across 14 psychiatric disorders Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar...