Ozempic and other GLP-1RAs - impact on ME/CFS

Article: Why Does Ozempic Cure All Diseases?

https://www.astralcodexten.com/p/wh...diseases?utm_campaign=post&triedRedirect=true

I believe that @leokitten has had some relief from MECFS at higher doses of Zepbound.

 

Who knows this could just be an ME fluctuation, but here’s my anecdote

Compared to LDA it’s harder for me to definitively attribute it to Zep because it’s 7 months of being on it and only the last two months on 10 mg and 12.5 mg have I noticed a slight improvement and stabilizing effect on my ME symptoms. It doesn’t prevent PEM or crashes like LDA can after exertion, but the last couple months I don’t have fluctuations in my energy envelope on a day to day basis like I used to. I now have more confidence that doing X amount of exertion within my envelope won’t cause significant PEM, whereas before I could do the same thing I did two days prior but this time suddenly crash. Before I never knew how I would feel day to day and what I could do, but the last two months when I get up every day I feel the same and know how much I can exert before PEM.

 

https://twitter.com/user/status/1807375484826902947



Multistep nominative determinism:
1. GLP-1RAs are being investigated as a way to suppress alcoholism
2. GLP-1RAs are based on a chemical found in Gila monster venom
3. Gila monsters were first described by zoologist Edward Drinker Cope



en.wikipedia.org
Edward Drinker

Ha!

 

OK but I still recommend that people read the article by Scott Alexander that I posted in the original post. He speculates about how these drugs may affect the immune system—might possibly be relevant to MECFS.

 

Tirzepatide cuts risk of diabetes by 94% in adults with prediabetes and obesity or overweight, drugmaker says

https://www.cnn.com/2024/08/20/health/tirzepatide-diabetes-lilly-trial/index.html

https://www.cnbc.com/2024/08/20/eli...uts-risk-of-developing-diabetes-in-trial.html


Wow!

 

https://www.cnn.com/2024/08/27/health/zepbound-tirzepatide-new-vials/index.html


Lilly launches lower-price weight loss drug without injector pen

Only 2.5 and 5mg doses

 

For UK people—does NHS give you GLP1 drugs for free?

 

There are a number of threads on r/cfs about these drugs too. Some people found it helped their symptoms, some didn’t. Doesn’t seem to be a magic cure all unfortunately..

 

Isn't suicidal ideation a possible side-effect of Ozempic and the others, or am I getting mixed up with another drug?

 

I'm not sure where to post this.

Kate Moss' half-sister Lottie, 26, says she ended up in the hospital after using Ozempic that she got from a friend.

NEW: 26-year-old model Lottie Moss overdoses on Ozempic, says she was rushed to the hospital and is now warning people against using the drug. Moss, the half-sister of Kate Moss, says she overdosed on Ozempic where she suffered a seizure. Moss says she weighed 130 pounds but was taking the dosage of someone twice her size. She says she quickly lost about 15 pounds before the overdose. "A few months ago, I was not feeling happy about my weight, I had a friend, and she could get it for me." "At the end of the day, it is a medication, it is dangerous and really meant for weight loss of people of a very large size." "When I was taking it, the amount that I was taking was meant for people who are 100 kilos and over and I'm in the 50s range." "It's these small things I wish I'd known before taking it. But I took it, you inject it into your leg, and it was the worst decision I ever made." "This is a warning to everyone. Please, if you're thinking of taking it, do not take it, it's so not worth it."

LINK

 

No one who weighs 130lbs should be taking weight loss medication.