Ozempic and other GLP-1RAs - impact on ME/CFS

Jaybee00 said:
https://www.astralcodexten.com/p/wh...diseases?utm_campaign=post&triedRedirect=true

I believe that @leokitten has had some relief from MECFS at higher doses of Zepbound.
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Who knows this could just be an ME fluctuation, but here’s my anecdote

Compared to LDA it’s harder for me to definitively attribute it to Zep because it’s 7 months of being on it and only the last two months on 10 mg and 12.5 mg have I noticed a slight improvement and stabilizing effect on my ME symptoms. It doesn’t prevent PEM or crashes like LDA can after exertion, but the last couple months I don’t have fluctuations in my energy envelope on a day to day basis like I used to. I now have more confidence that doing X amount of exertion within my envelope won’t cause significant PEM, whereas before I could do the same thing I did two days prior but this time suddenly crash. Before I never knew how I would feel day to day and what I could do, but the last two months when I get up every day I feel the same and know how much I can exert before PEM.
 
Jaybee00 said:
I believe that @leokitten has had some relief from MECFS at higher doses of Zepbound.
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On Zepbound:
Wikipedia said:
Tirzepatide is an antidiabetic medication used for the treatment of type 2 diabetes[10][13][14][15] and for weight loss.[11][16] Tirzepatide is administered via subcutaneous injections (under the skin).[10][13] It is sold under the brand names Mounjaro for diabetes treatment,[10] and Zepbound for weight loss.[11]. Tirzepatide is a GIP receptor and glucagon-like peptide-1 agonist.[11] (GLP-1RA)
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I'm not sure where to post this.

Kate Moss' half-sister Lottie, 26, says she ended up in the hospital after using Ozempic that she got from a friend.

NEW: 26-year-old model Lottie Moss overdoses on Ozempic, says she was rushed to the hospital and is now warning people against using the drug. Moss, the half-sister of Kate Moss, says she overdosed on Ozempic where she suffered a seizure. Moss says she weighed 130 pounds but was taking the dosage of someone twice her size. She says she quickly lost about 15 pounds before the overdose. "A few months ago, I was not feeling happy about my weight, I had a friend, and she could get it for me." "At the end of the day, it is a medication, it is dangerous and really meant for weight loss of people of a very large size." "When I was taking it, the amount that I was taking was meant for people who are 100 kilos and over and I'm in the 50s range." "It's these small things I wish I'd known before taking it. But I took it, you inject it into your leg, and it was the worst decision I ever made." "This is a warning to everyone. Please, if you're thinking of taking it, do not take it, it's so not worth it."

LINK
 
I have a friend who has had ME for over 30 years and just started Tirzepatide (Mounjaro) 12 weeks ago. She says ME symptoms as brain fog and sensitivity for light and sound has improved a lot and she can do much more than usual. Would love to hear your thoughts on this.
 
It’s official – Americans spent the same amount of money on weight loss injections as the country’s entire foreign aid budget in 2023. According to a study by the American Medical Association and the Centers for Disease Control, the figure spent on GLP-1 drugs – so named because they mimic the effects of a naturally occurring hormone called glucagon-like peptide-1 to lower blood sugar – hit a staggering $71bn. In the UK, research released in January 2025 and reported by the Telegraph revealed that more than one in 10 women are on the jabs in total, while an estimated 500,000 people are signed up to Mounjaro or Wegovy on a private prescription.
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As the takeup of these drugs, acquired via both the NHS and off-label prescriptions, continues on an ever-upward trajectory, more concerns are being raised about potential long-term side effects. A possible link with a deterioration in bone health and skeletal muscle mass has been flagged, with Dr Doug Lucas, a trauma and orthopaedic surgeon and director of education and training for Screen My Bones, calling it potentially “catastrophic” and “frightening”. Meanwhile, a large-scale study found that those taking GLP-1s were nearly 2.5 times more likely to develop drug-induced acute pancreatitis, a serious condition where the pancreas becomes inflamed.

Now, another warning has raised its head. Forget “Ozempic face”, the colloquial term for ageing and sagging facial skin, deepened lines or hollowed cheeks associated with rapid weight loss – should we be worrying about the even more unpleasant-sounding “Ozempic teeth”?
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Forget Ozempic face – should we be worried about Ozempic teeth?
 
It seems like these drugs are promoted for a lot of health complaints. But do we know enough about long term safety?

And even in the short term it seems these medications can cause harm.
 
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