People Want an Alzheimer’s Drug. This Isn’t the One. NY Times

https://www.nytimes.com/2021/05/28/...l?action=click&module=Opinion&pgtype=Homepage

They’ve spent billions on Alzheimer’s and sounds like they still have nothing. Worth reading even though it’s not about MECFS.

 

Finally, a realistic headline!

 

If I remember rightly, Professor Steven Rose was on about amyloid beta in connection with Alzheimer's many years ago, despite the fact that he found results similar to these. I challenged him vigorously at the Open University about it. Isn't it time that they sought the actual cause of this disease?

 

Sure you're aware that @Simon M has pointed out that GWAS has suggested clues re Alzheimer's.

 

https://www.nytimes.com/2021/06/07/...action=click&module=Spotlight&pgtype=Homepage

Approved.

 

Consequence 3: Doctors in the USA getting pressure from families to prescribe it off-label for loved ones with more advanced Alzheimer’s (for which it’s not indicated, only early MCI stage) because this is such a devastating disorder, burdening patient families and insurance companies with huge costs (cuz you know this is USA we move with the $ it’s gonna be $$$$) for a drug that likely will not work for more advanced Alzheimer’s.

 

I think since then not only discovery of the role of tau protein plus I believe very importantly the role of blood brain barrier damage/breakdown and insulin resistance and diabetes in the pathogenesis and progression of Alzheimer’s. BBB damage and leakage from diet, high blood pressure, diabetes, as well as brain cellular metabolic dysfunction due to insulin resistance I think are very plausible causes or major factors in the development of idiopathic (non APOE4 mutation) Alzheimer’s.

 

Yes - I studied Alzheimer's and all the probably-wrong theories for my Master's degree, and I think I found tau abnormalities a lot more likely to be a cause than amyloid-beta. But still they keep trying.

 

Well, it worked out for them... monetarily.