Persistent dysfunctions of brain metabolic connectivity in long-covid with cognitive symptoms, 2024, Martini et al.

Discussion in 'Long Covid research' started by SNT Gatchaman, Oct 16, 2024.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Persistent dysfunctions of brain metabolic connectivity in long-covid with cognitive symptoms
    Martini, Anna Lisa; Carli, Giulia; Caminiti, Silvia Paola; Kiferle, Lorenzo; Leo, Andrea; Perani, Daniela; Sestini, Stelvio

    PURPOSE
    Our study examines brain metabolic connectivity in SARS-CoV-2 survivors during the acute-subacute and chronic phases, aiming to elucidate the mechanisms underlying the persistence of neurological symptoms in long-COVID patients.

    METHODS
    We perfomed a cross-sectional study including 44 patients (pts) with neurological symptoms who underwent FDG-PET scans, and classified to timing infection as follows: acute (7 pts), subacute (17 pts), long-term (20 pts) phases. Interregional correlation analysis (IRCA) and ROI-based IRCA were applied on FDG-PET data to extract metabolic connectivity in resting state networks (ADMN, PDMN, EXN, ATTN, LIN, ASN) of neuro-COVID pts in acute/subacute and long-term groups compared with healthy controls (HCs). Univariate approach was used to investigate metabolic alterations from the acute to sub-acute and long-term phase.

    RESULTS
    The acute/subacute phase was characterized by hyperconnectivity in EXN and ATTN networks; the same networks showed hypoconnectivity in the chronic phase. EXN and ATTN hypoconnectivity was consistent with clinical findings in long-COVID patients, e.g. altered performances in neuropsychological tests of executive and attention domains. The ASN and LIN presented hyperconnectivity in acute/subacute phase and normalized in long-term phase. The ADMN and PDMN presented a preseverved connectivity. Univariate analysis showed hypometabolism in fronto-insular cortex in acute phase, which reduced in sub-acute phase and disappeared in long-term phase.

    CONCLUSIONS
    A compensatory EXN and ATTN hyperconnectivity was found in the acute/subacute phase and hypoconnectivity in long-term. Hypoconnectivity and absence of hypometabolism suggest that connectivity derangement in frontal networks could be related to protraction of neurological symptoms in long-term COVID patients.

    Link | PDF (European Journal of Nuclear Medicine and Molecular Imaging)
     
  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Methods —

     
  3. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Results —

    EXN is executive network
    ATTN is attentive network
    LIN is limbic network
    ASN is anterior salience network

     
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  4. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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