Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition, 2024, Khoramjoo et al.

Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition
Mobin Khoramjoo; Kaiming Wang; Karthik Srinivasan; Mahmoud Gheblawi; Rupasri Mandal; Simon Rousseau; David Wishart; Vinay Prasad; Lawrence Richer; Angela M. Cheung; Gavin Y. Oudit

BACKGROUND
A subset of individuals (10–20%) experience post-COVID condition (PCC) subsequent to initial SARS-CoV-2 infection, which lacks effective treatment. PCC carries a substantial global burden associated with negative economic and health impacts. This study aims to evaluate the association between plasma taurine levels with self-reported symptoms and adverse clinical outcomes in patients with PCC.

METHODS
and findings We analyzed the plasma proteome and metabolome of 117 individuals during their acute COVID-19 hospitalization and at the convalescence phase six-month post infection.

FINDINGS
were compared with 28 age and sex-matched healthy controls. Plasma taurine levels were negatively associated with PCC symptoms and correlated with markers of inflammation, tryptophan metabolism, and gut dysbiosis. Stratifying patients based on the trajectories of plasma taurine levels during six-month follow-up revealed a significant association with adverse clinical events. Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities and acute COVID-19 severity. In a multivariate analysis, increased plasma taurine level between acute and convalescence phase was associated with marked protection from adverse clinical events with a hazard ratio of 0.13 (95% CI: 0.05–0.35; p<0.001).

CONCLUSIONS
Taurine emerges as a promising predictive biomarker and potential therapeutic target in PCC. Taurine supplementation has already demonstrated clinical benefits in various diseases and warrants exploration in large-scale clinical trials for alleviating PCC.

Link | PDF (PLOS ONE) [Open Access]

 

Magnesium and taurine IM injections for 2.5 years was the best treatment I received for ME/CFS. The jabs reduced my breathlessness and improved my gait. Totally calmed my hyper-brain symptoms.

I wish I could have more of them.

 

It was recommended by Dr Paul Cheney for that kind of thing @Mij

I have always had some around since then and just put it in a drink if I feel I need to.

What I have found with longcovid is taurine had minimal effect but lysine on the other hand, taken with NAC, has a significant impact on headaches.

I would suggest to any LC researchers that they take a look at lysine.

From what I know of it, it appears to impact my vasodilation control by assisting calcium transport. That is as far as I have got with theory, but its a real effect whatever it is.

 

Yes, this is how I was able to convince my doctor to rx it for me because he attended one of Dr. Cheney's conferences back in 2001.

My taurine RBC levels on my amino acid test was in the mid levels, so not too low. We added it to the mg sulfate because taurine helps with the absorption of mg into the cells. The mg sulfate injections alone didn't give me any relief from the parkinsonism symptoms I had.

 

Aaaaah! Penny drops. Taurine for Mg, lysine for Ca. Very interesting. I desisted with taurine because I noticed headache spikes after taking it. But if that was because it was helping Mg out of the blood and into cells it would raise relative Ca in plasma, which I know makes my headaches worse. That would be consistent. Thanks for sharing.

 

But also to make nutrients. We need our biome for all sorts of things, and I am not sure we understand the full range or importance.

 

A sentence such as

to me, makes it seems like they started of with a hypothesis in relation to Taurine and then undertook a study to investigate that.

However, their setup very strongly suggests that this is not the case.

They performed hundreds of measurements on a very badly chosen cohort and then reported on one of the anomalies of those measurements, which given the setup, is probably just noise.