Friday May 22nd, 2026
Schedule
This item in particular piqued my interest:
Whole Genome Sequencing and Immune Profiling in Long COVID Petter Brodin, Karolinska
Dr. Brodin will present whole genome sequencing data from two cohorts of patients with severe Long COVID, highlighting candidate variants converging on key immune and immunometabolic pathways. Ongoing functional studies using patient-derived samples are defining how these variants alter immune responses to SARS-CoV-2 and other stimuli, with the goal of identifying mechanistic drivers of disease.
A couple of others:
Lael Yonker will talk on the recently published study Endovascular profiles linked to neutrophil activation in children and young adults with long COVID (2026)
Neutrophil-Driven Endothelial Injury and Microclot Formation in Long COVID Lael Yonker, U Texas SW
Dr. Yonker will present findings showing that children and young adults with Long COVID exhibit increased fibrin amyloid microclots, endothelial dysfunction, and elevated markers of neutrophil activation. Mechanistic studies demonstrate that Spike protein immune complexes trigger neutrophil extracellular trap (NET) formation, driving vascular injury and linking innate immune activation to persistent endovascular pathology and symptoms.
Direct Lymph Node Interrogation of Adaptive Immunity in Long COVID Michela Locci, U Penn
Dr. Locci will present findings from fine needle aspirates of cervical lymph nodes showing that germinal center B cell responses to SARS-CoV-2 are dysregulated in Long COVID. Her team is further investigating how Epstein Barr Virus reactivation within SARS-CoV-2–specific B cells may alter B cell function and contribute to defective antibody responses and viral persistence.
Schedule
This item in particular piqued my interest:
Whole Genome Sequencing and Immune Profiling in Long COVID Petter Brodin, Karolinska
Dr. Brodin will present whole genome sequencing data from two cohorts of patients with severe Long COVID, highlighting candidate variants converging on key immune and immunometabolic pathways. Ongoing functional studies using patient-derived samples are defining how these variants alter immune responses to SARS-CoV-2 and other stimuli, with the goal of identifying mechanistic drivers of disease.
A couple of others:
Lael Yonker will talk on the recently published study Endovascular profiles linked to neutrophil activation in children and young adults with long COVID (2026)
Neutrophil-Driven Endothelial Injury and Microclot Formation in Long COVID Lael Yonker, U Texas SW
Dr. Yonker will present findings showing that children and young adults with Long COVID exhibit increased fibrin amyloid microclots, endothelial dysfunction, and elevated markers of neutrophil activation. Mechanistic studies demonstrate that Spike protein immune complexes trigger neutrophil extracellular trap (NET) formation, driving vascular injury and linking innate immune activation to persistent endovascular pathology and symptoms.
Direct Lymph Node Interrogation of Adaptive Immunity in Long COVID Michela Locci, U Penn
Dr. Locci will present findings from fine needle aspirates of cervical lymph nodes showing that germinal center B cell responses to SARS-CoV-2 are dysregulated in Long COVID. Her team is further investigating how Epstein Barr Virus reactivation within SARS-CoV-2–specific B cells may alter B cell function and contribute to defective antibody responses and viral persistence.