Opinion Post-acute infection syndromes: time for recognition, understanding, and targeted care 2025 Wiersinga et al

[Andy]

Abstract​

Post-acute infection syndromes (PAIS) are conditions characterized by persistent symptoms following an infectious disease. Although these syndromes share similarities in symptom burden and impact on daily functioning, they vary significantly in aetiology, clinical course, and treatment options.

Postcovid is currently the most recognized example, but the phenomenon is not new: prolonged symptoms have also been observed after infections with Epstein-Barr virus, Borrelia burgdorferi, Coxiella burnetii, poliovirus, and after sepsis. The increasing attention to PAIS raises key questions in clinical practice: When do residual symptoms constitute a distinct syndrome? What do we know about underlying mechanisms and treatment strategies? How can we adequately diagnose and support patients? And what role does the biopsychosocial model play in understanding and managing these complaints?

In this Discussion article, we review recent scientific findings and offer a perspective on these discussion points, with the aim of improving recognition, insight, and patient-centred care in PAIS.

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[Andy]

Blog about the article.

Why the NTVG article about PAIS brings more confusion than recognition

RECOGNITIION, iNSIGHT AND TARGETED CARE IN THE NTVG ABOUT PAIS?

Phew. I had secretly hoped to finally see a truly good article in the NTVG. Although I can appreciate that an attempt was made to describe the biology of post-acute infectious syndromes (PAIS), unfortunately this was once again a disappointing and even very worrying and misleading piece. (1, 2)

A few points stood out to me. Because of a registration problem I could not consult the references, so I had to guess which studies were being cited.

Read more

 

[Alinda]

Blog about the article.

Why the NTVG article about PAIS brings more confusion than recognition

RECOGNITIION, iNSIGHT AND TARGETED CARE IN THE NTVG ABOUT PAIS?

Phew. I had secretly hoped to finally see a truly good article in the NTVG. Although I can appreciate that an attempt was made to describe the biology of post-acute infectious syndromes (PAIS), unfortunately this was once again a disappointing and even very worrying and misleading piece. (1, 2)

A few points stood out to me. Because of a registration problem I could not consult the references, so I had to guess which studies were being cited.

Read more

Makes me incredibly sad to read, but I am grateful we have someone like Anil to point it out..
Couldn't bear to read it all, truly makes me feel like the Netherlands just cannot make any progress. Just the same things, same mistakes over and over.