Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome, 2020, Fedorowski et al

Dolphin · Apr 25, 2020

Free full text:
https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01465-6

Research article

Open Access

Published: 22 April 2020

Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome

Jasmina Medic Spahic,

Fabrizio Ricci,

Nay Aung,

Erik Hallengren,

Jonas Axelsson,

Viktor Hamrefors,

Olle Melander,

Richard Sutton &

Artur Fedorowski

BMC Cardiovascular Disorders volume 20, Article number: 190 (2020) Cite this article
Click to expand...

Abstract
Background
Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology.

Methods
We conducted a nested case-control study within the Syncope Study of Unselected Population in Malmö (SYSTEMA) cohort including 396 patients (age range, 15–50 years) with either POTS (n = 113) or normal hemodynamic response during passive head-up-tilt test (n = 283). We used a targeted approach to explore changes in cardiovascular proteomics associated with POTS through a sequential two-stage process including supervised principal component analysis and univariate ANOVA with Bonferroni correction.

Results
POTS patients were younger (26 vs. 31 years; p < 0.001) and had lower BMI than controls. The discovery algorithm identified growth hormone (GH) and myoglobin (MB) as the most specific biomarker fingerprint for POTS. Plasma level of GH was higher (9.37 vs 8.37 of normalised protein expression units (NPX); p = 0.002), whereas MB was lower (4.86 vs 5.14 NPX; p = 0.002) in POTS compared with controls. In multivariate regression analysis, adjusted for age and BMI, and stratified by sex, lower MB level in men and higher GH level in women remained independently associated with POTS.

Conclusions
Cardiovascular proteomics analysis revealed sex-specific biomarker signature in POTS featured by higher plasma level of GH in women and lower plasma level of MB in men. These findings point to sex-specific immune-neuroendocrine dysregulation and deconditioning as potentially key pathophysiological traits underlying POTS.
Click to expand...

Log in or Sign up

Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome, 2020, Fedorowski et al

Dolphin Senior Member (Voting Rights)

Share This Page

Log in or Sign up

Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome, 2020, Fedorowski et al

Dolphin Senior Member (Voting Rights)

Share This Page

Useful Searches