biomarker

Multi-omic analysis of post-acute sequelae of COVID-19 (PASC) Abstract Millions of patients surviving COVID-19 infection develop post-acute sequelae of COVID-19 (PASC), a debilitating condition that severely disrupts quality of life. Limited data exists on PASC patient peripheral blood...

Oral Fluid Inflammatory Biomarker Profile in Long COVID: Evaluation of Oral Active and Total MMP-8, MMP-9, and TIMP-1 in Relation to BMI and Disease Status Abstract Background Long COVID (LC) is characterized by persistent systemic symptoms, but its oral inflammatory profile remains unclear...

Severity-associated endothelial dysfunction in post-COVID-19 patients: flow-mediated dilation and vasoactive biomarkers Abstract COVID-19 is frequently associated with endothelial dysfunction, characterized by an imbalance between vasodilatory and vasoconstrictive mediators. This study...

Long COVID shows IL-1 pathway dysregulation without a discrete circulating biomarker signature Abstract Long COVID (LC) is characterized by persistent and, often, disabling symptoms, yet its biological basis remains unclear. Multiple mechanisms, including immune dysregulation, endothelial...

Serum Cu/Zn ratio is significantly associated with long COVID Abstract Since the coronavirus disease 2019 (COVID-19) pandemic, many people have been affected by COVID-19. However, at present, neither reliable predictors of long COVID nor effective treatments are widely established. The aim...

Beyond genes: EpiSwitch® and Orion platform-powered 3D genome architecture biomarkers reveal shared biology across ME/CFS, long COVID, PTSD, rheumatoid arthritis, and multiple sclerosis Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID (LC19)...

Searching for biomarkers of long COVID: findings from a nationwide population-based study Abstract Long COVID, characterized by persistent symptoms following SARS-CoV-2 infection, affects an estimated 400 million people worldwide. The absence of reliable biomarkers has hindered progress...

Circulating Drivers of Pathophysiology in Post-COVID-19 Sequelae Abstract Introduction: According to the WHO, post-COVID-19 sequelae impose an increased burden of illness and comorbidities among survivors. The present study evaluated systemic clinical complications associated with the...

Clinical-cognitive profiles in long COVID and their associations with inflammatory-endothelial biomarkers and vascular measures Abstract Long COVID is clinically heterogeneous, and reproducible biomarker patterns remain limited. This cross-sectional study aimed to identify clinical-cognitive...

Circulating MicroRNA ratios as diagnostic biomarkers for long COVID with an independent validation cohort Abstract Background Long COVID is a multisystemic condition with heterogeneous clinical presentations lacking diagnostic biomarkers with discriminatory capacity. This study screened...

Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome Abstract Background Post-COVID-19 syndrome is a major long-term sequela of severe SARS-CoV-2 infection, potentially involving persistent angiogenic and thromboinflammatory dysfunction, though long-term biomarker...

Biomarkers of long COVID in children and young adults: a scoping review Bettina Camara, Danilo Buonsenso Abstract Following the SARS-CoV-2 pandemic, a significant percentage of people are now experiencing long-term symptoms, despite a continuing lack of concrete documentation of physiological...

Now published - see here Preprint Identification of a multi-omics factor predictive of long COVID in the IMPACC study Gisela Gabernet; Jessica Maciuch; Jeremy P Gygi; John F Moore; Annmarie Hoch; Caitlin Syphurs; Tianyi Chu; Naresh Doni Jayavelu; David B Corry; Farrah Kheradmand; Lindsey R...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown aetiology characterised by symptoms of post-exertional malaise (PEM) and fatigue leading to substantial impairment in functioning. Other key symptoms include cognitive impairment and...

Abstract Sleep deprivation enhances risk for serious injury and fatality on the roads and in workplaces. To facilitate future management of these risks through advanced detection, we developed and validated a metabolomic biomarker of sleep deprivation in healthy, young participants, across three...

full article Revolutionising Biomarker Discovery: The Role of High-Performance Liquid Chromatography

Proteomics International Laboratories Ltd (ASXIQ) Breakthrough Results For Endometriosis Diagnostic Blood Test

Katherine Huang, Alex G. C. de Sá, Natalie Thomas, Robert D. Phair, Paul R. Gooley, David B. Ascher & Christopher W. Armstrong Abstract Background Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and...

Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...

Plasma biomarkers in chronic single moderate–severe traumatic brain injury Gershon Spitz, Amelia J. Hicks, Stuart J. McDonald, Vincent Dore, Natasha Krishnadas, Terence J. O’Brien, William T O’Brien, Lucy Vivash, Meng Law, Jennie L. Ponsford, Christopher Rowe, Sandy R. Shultz Abstract Blood...