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Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunity, 2021, Oliveira et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Apr 30, 2021.

  1. Andy

    Andy Committee Member (& Outreach when energy allows)

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    Abstract

    Leprosy is a much‐feared incapacitating infectious disease caused by Mycobacterium leprae or M lepromatosis, annually affecting roughly 200,000 people worldwide. During host‐pathogen interaction, M leprae subverts the immune response, leading to development of disease. Throughout the last few decades, the impact of energy metabolism on the control of intracellular pathogens and leukocytic differentiation has become more evident. Mitochondria play a key role in regulating newly‐discovered immune signaling pathways by controlling redox metabolism and the flow of energy besides activating inflammasome, xenophagy, and apoptosis. Likewise, this organelle, whose origin is probably an alphaproteobacterium, directly controls the intracellular pathogens attempting to invade its niche, a feature conquered at the expense of billions of years of coevolution. In the present review, we discuss the role of reduced host cell mitochondrial activity during M leprae infection and the consequential fates of M leprae and host innate immunity. Conceivably, inhibition of mitochondrial energy metabolism emerges as an overlooked and novel mechanism developed by M leprae to evade xenophagy and the host immune response.

    Paywall, https://onlinelibrary.wiley.com/doi/10.1111/imr.12962
     
    merylg, Lisa108, Hutan and 8 others like this.
  2. Mithriel

    Mithriel Senior Member (Voting Rights)

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    Another fascinating insight into the complex interactions of parasites with our basic biochemistry. It really does make the BPS views look like a child's version of biology.
     
    Lisa108, Hutan, alktipping and 6 others like this.

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