I was recently thinking about this idea in relation to Wessely's outpourings between 1989 and 1991, all apparently based largely on the same cohort of 50 patients of whom 30 accepted treatment. 20 fulfilled criteria for probable or major depression and were offered tricyclic antidepressants (3 of them refused). A further 3 fulfilled criteria for other psychiatric disorders and were offered similar treatment.
In fairness, Wessely did state that "we have not conducted a randomised, controlled trial, but a pilot study, the necessary preliminary to a more formal assessment". It is a shame that all those influenced by these papers seem not to have been interested in that qualifying of the findings.