Ron Davis: Grant award: Molecular and single-cell immunology in ME/CFS

https://www.youtube.com/watch?v=vZQgJP47kA4

around 24:00 to 26:00

eta: he did mention it in more detail at another conference but I can't remember which one.

 

Ongoing, so far as I'm aware. Beyond saying that the SGTC team is still working on it -- and because they're still working on it -- I shouldn't say anything else.

 

Great to hear that money are comming. I think with The Pineapple Fund donation, OMF, NIH and many donors - Stanford research team will not be far away form the budget 10 mil. USD a year. I think this can really move the research on Stanford. It would be great to have such a team with that budget also in UK. What to do about it?
I followed some crowdfunding campaigns for research projects in UK (IiME,...) but they were able to get only 100 000 a year, i never understood why so little.

 

Thats one year....Pine won't be coming in again, they are nowhere near 10 million per year really...

 

I did wonder if this was some form of autoantibody stuck on translocator membranes as postulated by Prof Behan in 1980s .

There are a lot of interesting studies which got sidetracked after BPS hijacked agenda - which are being rediscovered- eg sticky blood. These are not new phenomena, just forgotten.

It would be worthwhile trawling past research in pertinent areas- given the technology and processes now available who knows where thus may lead ?

 

Still freelancing for Stanford sometimes, and looking into some of those older theories that were never disproved, just... left sitting there, waiting on more money and better interest.

 

A transcript is now available at https://www.omf.ngo/2018/07/05/ron-davis-nih-grant/
Direct link to the pdf here.

 

Anyone got an update i.e. when is it due to report? 2018 + 5 years = 2023!

 

Happened to be reading this
Genetic risk factors of ME/CFS: a critical review
Joshua J Dibble, Simon J McGrath, Chris P Ponting
And noticed this reference:
"The MHC locus and genetic susceptibility to autoimmune and infectious diseases"
29.Matzaraki, V., Kumar, V., Wijmenga, C. and Zhernakova, A. (2017) The MHC locus and genetic susceptibility to autoimmune and infectious diseases Genome Biol.

So the Stanford study may test whether ME/CFS has a strong MHC/HLA "autoimmune and infectious diseases" link?

 

any chance this could be the WASF3?

 

The paper said —

So I don't think it would be WASF3 itself, but perhaps instead it's something impairing the ER stress response (via eIF2a) that then induces increased intracellular WASF3.

(Maybe the upstream mechanism involves one or more microRNAs or circRNAs??)