SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in a hamster model, 2025, Sardarni et al.

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  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in a hamster model
    Kaur Sardarni; Ambikan; Acharya; Johnson; Avedissian; Végvári; Neogi; Byrareddy

    Despite significant effort, a clear understanding of host tissue-specific responses and their implications for immunopathogenicity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection has remained poorly defined.

    To shed light on the interaction between tissues and SARS-CoV-2 variants, we sought to characterize the complex relationship among acute multisystem manifestations, dysbiosis of the gut microbiota, and the resulting implications for SARS-CoV-2 variant-specific immunopathogenesis in the Golden Syrian Hamster (GSH) model using multi-omics approaches.

    Our investigation revealed the presence of increased SARS-CoV-2 genomic RNA in diverse tissues of delta-infected GSH compared to the omicron variant. Multi-omics analyses uncovered distinctive metabolic responses between the delta and omicron variants, with the former demonstrating dysregulation in synaptic transmission proteins associated with neurocognitive disorders. Additionally, delta-infected GSH exhibited an altered fecal microbiota composition, marked by increased inflammation-associated taxa and reduced commensal bacteria compared to the omicron variant.

    These findings underscore the SARS-CoV-2-mediated tissue insult, characterized by modified host metabolites, neurological protein dysregulation, and gut dysbiosis, highlighting the compromised gut-lung-brain axis during acute infection.

    Link | PDF (Brain, Behavior, and Immunity)
     
    Last edited: Nov 11, 2024
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  2. Dolphin

    Dolphin Senior Member (Voting Rights)

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    Highlights

    • Delta variant showed higher viral RNA in multiple organs than omicron in hamsters.

    • Distinct metabolic responses in major organs of delta vs. omicron-infected hamsters.

    • Delta infection imprints dysregulated synaptic protein signature in hamsters brain.

    • Delta infection caused gut dysbiosis with increased inflammation-associated taxa.
     
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  3. Dolphin

    Dolphin Senior Member (Voting Rights)

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