gut microbiome

GLP-1 Receptor Agonists, Gut Microbiota, and Chronic Pain: Nutritional Signaling at the Gut–Brain Axis Abstract Background/Objectives: Chronic pain affects more than one in five adults worldwide and is increasingly conceptualized as a disorder of the gut–brain axis. Gut microbial dysbiosis...

The Gut Microbiome in Multiple Sclerosis Sánchez-Sanz, Alicia; Baranzini, Sergio E. Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS whose risk and course are shaped by both genetic and environmental factors, among which the intestinal microbiota has...

Progressive Post-Acute Gut Microbiome Disruption Following SARS‑CoV‑2 Infection in Mice Abstract SARS‑CoV‑2 infection is increasingly recognized to produce long‑lasting physiological disturbances that extend beyond the acute phase. The gut microbiome has emerged as a potential contributor to...

Microbiome dysbiosis in long COVID: a scoping review of mechanistic insights, symptom associations, and therapeutic targets Abstract Background The human microbiome, particularly the gut microbiome, plays a critical role in host immunity, metabolism, and barrier function. Emerging evidence...

Functional enrichment of immune targeted gut microbiota in post-infectious myalgic encephalomyelitis/chronic fatigue syndrome Abstract Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a debilitating condition characterized primarily by profound fatigue and...

Tryptophan Metabolism and Aryl‐Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease with unknown biological basis and no...

Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population. Brain-extrinsic factors influencing cognitive decline, such as gastrointestinal signals, have emerged as attractive targets for peripheral interventions but the underlying...

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID Post COVID-19 condition (Long COVID, LC) is frequently accompanied by persistent neurological symptoms, but the mechanisms linking intestinal dysbiosis to neuroinflammation remain...

A cellular basis for heightened gut sensitivity in females Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fibers likely contributes to this sex...

Abstract Connections between the digestive system and the brain have been postulated for over 2000 years. Despite this, only recently have specific mechanisms of gut-brain interaction been identified. Due in large part to increased interest in the microbiome, the wide use of incretin-based...

Xinxin Cheng, Wenkuan Wang, Tingting Xu, Yanjie Wang, Xina Zhen, Wenxuan Man, Shuo Gao & Yonghui Yin Abstract To investigate differences in gut microbiota composition and short-chain fatty acids (SCFAs) metabolism between patients with Chronic Fatigue Syndrome (CFS) and Healthy Controls (HC)...

Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility. Functional...

Full Title: Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision=based randomized placebo-controlled trial, 2025, Elizabeth Sun et al Abstract Background Carnobacterium maltaromaticum and Faecalibacterium...

The gut microbial composition is different in chronic fatigue syndrome than in healthy controls Monika Prylińska-Jaśkowiak, Hanna Tabisz, Sławomir Kujawski, Beata R. Godlewska, Joanna Słomko, Beata Januszko-Giergielewicz, Modra Murovska, Karl J. Morten, Łukasz Sokołowski & Paweł Zalewski [Line...

Full title: Advancing Digital Precision Medicine for Chronic Fatigue Syndrome through Longitudinal Large-Scale Multi-Modal Biological Omics Modeling with Machine Learning and Artificial Intelligence We studied a generalized question: chronic diseases like ME/CFS and long COVID exhibit high...

Link to published paper here Preprint: Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive...

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation White, Zachary; Cabrera, Ivan; Mei, Linghan; Clevenger, Margarette; Ochoa-Raya, Andrea; Kapustka, Isabel; Dominguez, Joseph R.; Zhou, Jinyan; Koster, Kevin P.; Anwar, Shehata; Wang, Qianxun; Ng, Charles; Sagoshi...

Abstract Gut bacteria-derived metabolites, such as butyrate (BUT), induce T regulatory cells through inhibition of histone deacetylases (HDAC). Natural killer (NK) cells are innate lymphocytes with important effector and regulatory functions; little is known on the effect of BUT on NK cells...

Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects Orlando DeLeon; Mora Mocanu; Alan Tan; Ashley M. Sidebottom; Jason Koval; Hugo D. Ceccato; Sarah Kralicek; John J. Colgan; Marissa M. St. George; Joash M. Lake; Michael Cooper...

Scientists invent tool to see how 'healthy' your gut microbiome is — does it work?