Classically, internal sensations such hunger, satiety, and sickness are mediated by vagal sensory neurons that reside in the nodose ganglia. Beyond sensing somatic inputs, recent studies are shedding new light on the importance of spinal sensory neurons within the DRG in regulating a variety of visceral physiologies. However, the spectrum of symptoms and the mechanisms underlying noxious sensations from the viscera remain poorly understood. Here, we identify a unique subpopulation of DRG sensory neurons that respond to cues from two distinct organs and critically mediate the development of interorgan visceral hypersensitivity. The existence of polyorganic sensory neurons may explain what drives multiorgan visceral pain syndromes, and why visceral pain is so difficult to localize.