This is from New England Journal of Medicine's Journal Watch. https://blogs.jwatch.org/hiv-id-obs...he-shingles-vaccine-answered-here/2019/10/14/ October 14th, 2019 Common Questions About the Shingles Vaccine — Answered Here! Here’s an interesting email from my friend and ID-colleague Dr. Carlos Del Rio (shared with his permission): Went Tuesday to see my PCP for a routine visit and had my second dose of Shingrix that day. I had gotten my first dose about 3 months ago and had severe chills and even a fever of 38.5 after the first dose. With the second dose the response was not as severe but did have chills and rigors for about 18 hrs. Stupid of me, but the next day I went to get my labs checked, and everything was fine except my HS-CRP which was 14.72 (nl < 10 and in the past I had been < 1.0). Anyway…..Shingrix is a good vaccine but it is a tough one to take and really gives you a nice TNF storm! The rest is at the link.
On my list for next year. I will have to get it privately as the NHS is limiting it to people a fair bit older than me so I doubt even if it is extended it would include my age group any time soon.
Is there any suggestion whether the shingles vaccine is recommended for PWMECFS? My MECFS physician was not recommending this vaccine to their patients, but I do not know of any evidence that suggests that the new vaccine (or even the old one) is harmful to PWMECFS. Any thoughts about this?
I had the shingles vaccine a few months ago. In the UK it is offered when you turn 70. I had no noticeable side effects from it, nor any effect on my ME. Shingles sounds pretty horrible. I preferred to have the vaccine. It was a single dose. Maybe it's different from the US one.
I've been advised that it's fairly unlikely I'd get shingles a second time, so it's one vaccine choice I don't have to make (unless the advice has changed by the time I get to 70). Mine only got diagnosed because I happened to have an appointment at the surgery to have stitches removed. There was a little rash going in a line across my back, which I realised was a bit tender when the nurse got the GP to examine it, but I had no other symptoms. I don't think I'd have known I'd had it otherwise. The only difficult bit was when someone else developed it a few weeks later, and we had to try and convince two particular colleagues that shingles itself isn't transmissible. We'd both checked that people in our respective offices had definitely had chickenpox before continuing going in to work with it...we never quite convinced them that we weren't spreading a shingles epidemic, though!
I've just had a look and the UK vaccine for shingles is a single dose of Zostavax. https://www.nhs.uk/conditions/vaccinations/shingles-vaccination/
Shingrix is expensive (new, more effective than Zostavax) and because of its effectiveness (maybe because of the adjuvant?-- which is the chemical that prods your immune system into action) side effects of the vaccine can be strong: sore arm, muscle aches, fever, etc. This means the immune system is activated (a good thing). Probably the UK will get on board with Shingrix when the price drops (generic comes out).
Good to be reassured by the effectiveness and safety findings. I'm about to take the huge financial plunge and have the two Shingrix vaccinations. The protection from both infection and post-herpetic neuralgia is far superior. According to nps.org.au, the older vaccine, Zostavax, is only 51% effective at preventing infection and 67% effective at preventing post-herpetic neuralgia. In Australia Zostavax is free for over 70s but Shingrix isn't. Shingrix will cost me about $560 (about £315) for the two injections. The lifetime risk is 22% for men and 32% for women. I assume that's 32% of only those who have had chicken pox. It's quite common anyway. Big decision.
My province's immunization program transitioned from Zostovax to Shingrix vaccine a couple of years ago. Seniors ages 65 to 70 years will get the two dose Shingrix for free. So I'm waiting five years until I'm eligible.
I am about to get the second of my Shingrix course, in a week. Not exactly looking forward to it, as the reaction to the first one was the worst I have had for any vaccine. It wasn't disaster level, and passed within a week. But it was pretty unpleasant for the first 2-3 days, and I will be making sure my fridge is full and my calendar free for the week after it. I am a way off 70, but my father offered to pay, and I can't afford any more health complications, and shingles is not something you want to get. After that is over, I will be looking at getting a new multivalent Covid vax.
Had my second Shingrix two days ago. A lot less of a problem than the first one. Did feel moderately shitty the day after, and I still have a bit of a sore arm. But nothing like what happened with the first dose.
I had my first Shingrix vaccination last week. For the first time ever I had a reaction to a vaccine, not counting sore arms. I felt very unwell for about 15 hours then I was fine. No big deal but it was a surprise. After just noticing this new thread - https://s4me.info/threads/zoster-as...increased-stroke-risk-2022-bubak-et-al.31053/ - I'm glad I made the decision to go with Shingrix.
My second Shingrix vaccination was completely uneventful - not even a particularly sore arm. Despite the eye-watering AUD$570 price tag I feel relieved to have potentially saved myself from the worst of yet another nasty disease.
New long-term data show Shingrix continues to provide high protection against shingles in adults aged 50 and over for more than a decade. • End-of-trial data show 79.7% efficacy in participants aged 50 years and over, six to 11 years after vaccination1 • Vaccine efficacy remains high at 82.0% at year 11 after initial vaccination1 • No new safety concerns were identified during the follow-up period PDF
