vaccine

SARS-CoV-2 spike protein-associated sialoglycoconjugates induce nanoscale filipodia to facilitate micro-size platelet clotting COVID-19 disease is associated with thrombosis, but the pathogenic mechanism remains unclear. Here, we investigate how SARS-CoV-2 spike protein causes platelet...

https://www.msn.com/en-gb/health/other/major-trial-for-human-bird-flu-vaccine-launches/ar-AA21qeYJ?uxmode=ruby&ocid=edgntpruby&pc=U531&cvid=69e89733ac2041f68cb3fd620d7db233&ei=21

Global estimates of vaccine-associated narcolepsy from 1967 to 2023 Regional evidence on the signal detection between narcolepsy and vaccines is scarcely available and insufficiently understood, thus impeding a comprehensive understanding of this relationship on a global scale. Therefore, this...

Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis...

Article in The Atlantic (paywall): Do Childhood Vaccines Cause Tornadoes? It hasn’t been ruled out. Link to same article on MSN (no paywall): https://www.msn.com/en-us/science/general/do-childhood-vaccines-cause-tornadoes/ar-AA1QV10w

Abstract Injected COVID-19 vaccines protect against severe disease, but do not induce robust mucosal immune responses. Nasal vaccines offer the advantage of local immunity to block viral infection and transmission. Previously we showed immunization of a Pam2Cys-adjuvanted SARS-CoV-2 vaccine to...

Study finds no evidence aluminum salts in vaccines are tied to higher risk of asthma, other childhood diseases

[Posted on behalf of @MSEsperanza] https://brieflands.com/articles/jamm-12285.html Background: The medical community fails dramatically in the understanding of chronic diseases and development of causal therapies. Statistical associations between vaccinations or infections and autoimmune...

Assessment of Myocardial 18F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2–vaccinated and Nonvaccinated Patients Authors: Takehiro Nakahara et al Published Online: Sep 19 2023 Abstract Background Patients who developed myocarditis after SARS-CoV-2 vaccination show abnormalities on cardiac...

I’ve heard a few stories about the impact of HPV vaccination on cervical cancer rates in the UK and elsewhere recently but this has some of the best graphs and charts to visualise it all worldwide https://ourworldindata.org/hpv-vaccination-world-can-eliminate-cervical-cancer

Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work‐up and decision points for vaccination during the COVID‐19 pandemic Abstract Background During the COVID‐19 pandemic focus has been on polyethylene glycol (PEG) and polysorbate as these excipients are...

SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck Tommy S. Tillman; Qiang Chen; Vasyl Bondarenko; Jonathan A. Coleman; Yan Xu; Pei Tang A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune...

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics Lee, Yeji; Jeong, Michaela; Park, Jeongeun; Jung, Hyein; Lee, Hyukjin Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and...

Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study Lisa Lundberg-Morris; Susannah Leach; Yiyi Xu; Jari Martikainen; Ailiana Santosa; Magnus Gisslén; Huiqi Li; Fredrik Nyberg; Maria Bygdell Objectives To investigate...

Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice Dasari, Vijayendra; McNeil, Lisa K.; Beckett, Kirrilee; Solomon, Matthew; Ambalathingal, George; Thuy, T. Le; Panikkar, Archana; Smith, Caitlyn; Steinbuck, Martin P.; Jakubowski, Aniela...

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis Lael M. Yonker; Zoe Swank; Yannic C. Bartsch; Madeleine D. Burns; Abigail Kane; Brittany P. Boribong; Jameson P. Davis; Maggie Loiselle; Tanya Novak; Yasmeen Senussi; Chi-An Cheng; Eleanor Burgess; Andrea G. Edlow...

Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Claudia Cicala, James Arthos, John H Kehrl (National...

Vaccination induces HIV broadly neutralizing antibody precursors in humans https://www.science.org/doi/10.1126/science.add6502

GSK’s older adult respiratory syncytial virus (RSV) vaccine candidate shows 94.1% reduction in severe RSV disease and overall vaccine efficacy of 82.6% in pivotal trial Data to be presented at IDWeek 2022 showed overall vaccine efficacy against RSV-lower respiratory tract disease (LRTD) in...

A recording of the 2022 Institute for Neuro-Immune Medicine (INIM) Conference, held on June 10, has been posted to YouTube.