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Sore throats swollen glands

Discussion in 'Other Symptoms' started by NelliePledge, May 5, 2019.

  1. Hutan

    Hutan Moderator Staff Member

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    It seems as though a substantial percentage of us have a sore throat as part of PEM, or more often:
    Poll - Sore throat and tender lymph nodes

    Has any work been done to work out what is going on with this? There is so much done with the symptom of fatigue, but maybe some work on the other symptoms might give us a clue.

    I remember mentioning to a doctor once that I often get a sore throat with PEM, and that I have wondered what causes that, and what a biopsy or even just looking at the throat when it was sore might show. He confidently replied that it would show nothing, although I have no idea how he could know that. He certainly wasn't an expert on ME literature.

    What could cause the PEM sore throat? And is there any way we could try to check out some of the possibilities?
     
    Philipp, Ravn, alktipping and 6 others like this.
  2. Ravn

    Ravn Senior Member (Voting Rights)

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    Good question. I've always assumed - based on no evidence whatsoever - that the sore throat is part of the general sickness response symptom cluster. Like when you're coming down with a cold or flu. Confused immune system attacking ghosts or something. But really I've no idea.

    A quick google didn't find much, sore throat is listed as a symptom often enough but nobody seems to have looked into it further. I did find this general paper on non-infectious sore throats (not in ME). Seems they're not well understood even before we add ME to the mix. From the conclusion:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439613/

    And I found this (beware: it leads down the rabbit hole of HPV vaccine):
    https://www.meresearch.org.uk/nose-and-throat-inflammation/
     
  3. Kitty

    Kitty Senior Member (Voting Rights)

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    I never get the PEM sore throat without swollen lymph nodes. Someone once explained that they swell because they've recruited additional blood cells to come and fight an infection, and because of this I assume there's some kind of immune component to PEM.

    If the PEM is mild, my swollen nodes usually go down within a couple of hours; I treat it as a useful warning that I need to cut back on everything except necessary activities for a little while. If it's severe, they'll stay that way for days.

    I'd like to know what triggers this response, and how it gets subdued again, sometimes very quickly.
     
    Ravn, MarcNotMark, alktipping and 2 others like this.
  4. MeSci

    MeSci Senior Member (Voting Rights)

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    My lymph nodes have been permanently swollen for years now, I think. They used to go down, but not any more.
     
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  5. NelliePledge

    NelliePledge Moderator Staff Member

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    Presumably assumptions have been made that there’s nothing exceptional about it but are there other illnesses where you can get sore throat and swollen glands from participating in activity?
     
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  6. Kitty

    Kitty Senior Member (Voting Rights)

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    I wonder if this has anything useful to say about people who worsen permanently after activity that takes them beyond the PEM threshold, or after another illness?
     
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  7. Forbin

    Forbin Senior Member (Voting Rights)

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    I had this for years after onset and assumed it was probably connected to the sore throat feeling, although I could have them independent of each other. The kind of odd thing was that when I told others that my voice was hoarse, even members of my immediate family said it sounded normal to them. I was dumbfounded that it wasn't noticeable to them. I could certainly feel the rasp in my throat and could hear it in my ears but others could not. Maybe it was because my voice is normally quite deep. The hoarseness might have been more apparent to others if my voice were normally of a higher pitch.
     
    Philipp, Ravn, alktipping and 4 others like this.

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