It seems as though a substantial percentage of us have a sore throat as part of PEM, or more often: Poll - Sore throat and tender lymph nodes Has any work been done to work out what is going on with this? There is so much done with the symptom of fatigue, but maybe some work on the other symptoms might give us a clue. I remember mentioning to a doctor once that I often get a sore throat with PEM, and that I have wondered what causes that, and what a biopsy or even just looking at the throat when it was sore might show. He confidently replied that it would show nothing, although I have no idea how he could know that. He certainly wasn't an expert on ME literature. What could cause the PEM sore throat? And is there any way we could try to check out some of the possibilities?