Stacking the odds: Multiple sites for HSV-1 latency, 2023, Shaohui Wang et al

Discussion in 'Other health news and research' started by Mij, Jan 30, 2023.

  1. Mij

    Mij Senior Member (Voting Rights)

    Messages:
    8,613
    The herpes simplex virus hides in the body’s immune cells, increasing its survival chances. This finding from offers a new target for vaccines to clear latent infection.

    Abstract
    A hallmark of herpes simplex virus (HSV) infection is the establishment of latent virus in peripheral sensory ganglia of the latently infected host. We and others originally reported that the latency-associated transcript (LAT) is the only abundantly expressed viral gene in neurons within trigeminal ganglia (TG) of a latently infected host.

    Here, we investigated the possible contribution of various cells [i.e., B cells, dendritic cells (DCs), fibroblasts, glial cells, innate lymphoid cells (ILCs), macrophages, microglia, monocytes, natural killer cells, neurons, neutrophils, and T cells] isolated from TG of latently infected mice.

    Our results demonstrated that all of these cell types contain LAT, with DCs, neurons, and ILCs having the most LAT+ cells. These results suggest that HSV-1 can establish a quiescent/latent infection in a subset of nonneuronal cells, which enhances the chances that the virus will survive in its host.


    https://www.science.org/doi/10.1126/sciadv.adf4904
     

Share This Page