Stanford Community Symposium 2018: OMF Studies - Xiao and Davis

[NelliePledge]

This thread has been split from the Stanford Community Symposium 2018 thread.
It covers the presentation by Wenzhong Xiao and comments related to OMF studies (e.g. Severely Ill Patient Study) by Ron Davis.

Did I hear Xiao say BDNF being different was a new finding?? There have been others from what I remember including at Newcastle

 

[mariovitali]

Did i hear Wenzhong Xiao mention Network Analysis and Machine Learning ???

 

[Hoopoe]

(copied post)

Hanson seems optimistic about metabolomics results. She thinks the inability to find subgroups in patients with metabolomics approach suggests that the abnormalities are fundamental to the illness. At least that is what I understood. The presentations so far have not been easy to follow.

Edit: also Xiao said that the TRPM3 gene doesn't show up as significant in their analysis of severely ill patients.

My personal impression is that many researchers are struggling with the heterogeneity of patients, so Hanson's optimism is comforting.

 

[Sly Saint]

And Ron Davis explained that the virus testing they did with blood would show any viruses anywhere in the body [edit - and they found less than in healthy controls].

would this suggest that pwME s Virome is out of whack too?

(article on Human Virome :
"Perhaps the most interesting development of the study of the virome is the interplay that viruses can have with other components of the microbiome, specifically bacteria, that can either up- or down-regulate the antiviral immune response and can therefore modulate viral infectivity.

This relationship is reciprocal since viruses can in turn modulate bacterial infections. The complex interactions of the virome with other members of the microbiome in the context of host genetics, and their influence in the health status of the patient have just begun to be investigated and are not completely understood, but the findings so far indicate that the regulation of the immune response by viruses and other members of the microbiome can affect the outcome of infections.")

https://www.sciencedirect.com/science/article/pii/S0188440918300262

eta: presumably the people in Rons study had not been on anti-virals(?)

found another interesting article:
Human oral viruses are personal, persistent and gender-consistent

"As has previously been demonstrated for bacteria and fungi, membership in the oral viral community was significantly associated with the sex of each subject."

https://www.nature.com/articles/ismej201431