Subcortical and Default Mode Network connectivity is impaired in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2023 Inderyas et al

[Sly Saint]

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic condition with core symptoms of fatigue, and cognitive dysfunction suggesting a key role for the central nervous system, in the pathophysiology of this disease. Several studies have reported altered functional connectivity (FC) related to motor and cognitive deficits in ME/CFS patients. In this study, we compared functional connectivity differences between 31 ME/CFS and 15 healthy controls (HC) using 7 Tesla MRI.

Functional scans were acquired during a cognitive Stroop color-word task and blood oxygen level-dependent (BOLD) time-series were computed for 27 regions of interest (ROIs) in the cerebellum, brainstem, and salience and default mode networks. Region-based comparison detected reduced FC between the pontine nucleus and cerebellum vermis IX (p=0.027) for ME/CFS patients compared to HC. Our ROI-to-voxel analysis found significant impairment of FC within ponto-cerebellar regions in ME/CFS.

Correlation analyses of connectivity with clinical scores in ME/CFS patients detected associations of FC with ‘duration of illness’ and ‘memory scores’ in salience network hubs and cerebellum vermis, and with ‘respiratory rate’ within medulla and the default mode network FC. This novel investigation is the first to report extensive involvement of aberrant ponto-cerebellar connections consistent with ME/CFS symptomatology. This highlights the involvement of the brainstem and the cerebellum in the pathomechanism of ME/CFS.

https://www.frontiersin.org/articles/10.3389/fnins.2023.1318094/abstract

 

[Sid]

This novel investigation is the first to report

When I saw this bit, I knew who the author would be without even clicking on the link.

 

[Dolphin]

The full text has now been published:
https://www.frontiersin.org/articles/10.3389/fnins.2023.1318094/full

Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research is funded by ME Research UK (SCIO Charity Number SC036942) with the financial support of The Fred and Joan Davies Bequest. Other funding bodies include: the Stafford Fox Medical Research Foundation (489798), the National Health and Medical Research Council (1199502), McCusker Charitable Foundation (49979), Talei Stewart, Buxton Foundation (4676), Henty Community (4879), Henty Lions Club (4880), Mr. Douglas Stutt, Blake Beckett Trust Foundation (4579), Alison Hunter Memorial Foundation (4570), and the Change for ME Charity (4575).

https://twitter.com/user/status/1751960012283371789

 

[Dolphin]

ME Research UK

Dr Leighton Barnden and his team at Griffith University have recently published more findings from their ME Research UK-funded study using advanced imaging techniques to look at brain abnormalities in people with ME/CFS. They found that functional connectivity was impaired between several different areas of the brain, highlighting involvement of the brainstem and cerebellum in ME/CFS.

Read more: https://www.meresearch.org.uk/research/brain-functional-connectivity-in-people-with-me-cfs/