Sulfur Dioxide and POTS

[Jenny TipsforME]

Increased Endogenous Sulfur Dioxide Involved in the Pathogenesis of Postural Tachycardia Syndrome in Children: A Case‐Control Study

Hong‐Xia Li1, Xiao‐Chun Zheng1, Si‐Yao Chen2, Ying Liao1, Zhen‐Hui Han3, Pan Huang1, Chu‐Fan Sun1, Jia Liu1, Jing‐Yuan Song1, Chao‐Shu Tang4, Jun‐Bao Du1, Yong‐Hong Chen1, Hong‐Fang Jin1

Abstract

Background: The pathogenesis of postural tachycardia syndrome (POTS) remains unclear. This study aimed to explore the changes and signi cance of sulfur dioxide (SO2) in patients with POTS.

Methods: The study included 31 children with POTS and 27 healthy children from Peking University First Hospital between December 2013 and October 2015. A detailed medical history, physical examination results, and demographic characteristics were collected. Hemodynamics was recorded and the plasma SO2 was determined.

Results: The plasma SO2 was signi cantly higher in POTS children compared to healthy children (64.0 ± 20.8 μmol/L vs. 27.2 ± 9.6 μmol/L, respectively, P < 0.05). The symptom scores in POTS were positively correlated with plasma SO2 levels (r = 0.398, P < 0.05).

In all the study participants, the maximum heart rate (HR) was positively correlated with plasma levels of SO2 (r = 0.679, P < 0.01). The change in systolic blood pressure from the supine to upright (ΔSBP) in POTS group was smaller than that in the control group (P < 0.05). The ΔSBP was negatively correlated with baseline plasma SO2 levels in all participants (r = −0.28, P < 0.05).

In the control group, ΔSBP was positively correlated with the plasma levels of SO2 (r = 0.487, P < 0.01). The change in HR from the supine to upright in POTS was obvious compared to that of the control group.

The area under curve was 0.967 (95% con dence interval: 0.928–1.000), and the cutoff value of plasma SO2 level >38.17 μmol/L yielded a sensitivity of 90.3% and a speci city of 92.6% for predicting the diagnosis of POTS.

Conclusions: Increased endogenous SO2 levels might be involved in the pathogenesis of POTS.

http://www.cmj.org/temp/ChinMedJ1314435-5425603_150416.pdf

Edit: that link isn’t working try http://www.cmj.org/article.asp?issn...ume=131;issue=4;spage=435;epage=439;aulast=Li

 

[Jenny TipsforME]

I had this in my inbox from ncbi no idea if this is important or credible. My brain won’t allow me to read the full article but the dots on the graphs look close to the line (it does look like this is a thing).

 

[pteropus]

interesting. POTS was one of my earliest symptoms, and sulfur dioxide (E220 preservative) makes me feel ill.

sulfur dioxide can cause vasodilation, and other cardiovascular problems, which fits with this theory. it can be reduced by taking n-acetyl-cysteine and glutathione.
https://en.wikipedia.org/wiki/Sulfur_dioxide#Biochemical_and_biomedical_roles

i'm wondering if the local air pollution (Peking) contributed to the subjects' sulfur dioxide levels.

 

[Jenny TipsforME]

For some reason the link I initially added doesn’t work. Try http://www.cmj.org/article.asp?issn...ume=131;issue=4;spage=435;epage=439;aulast=Li