Preprint Systems Modeling Reveals Shared Metabolic Dysregulation and Novel Therapeutic Treatments in ME/CFS and Long COVID, 2024, Gong-Hua et al

I should add that Aspartate has one N atom.

This N atom in Aspartate is actually the N in NO.

I don't think a lot of people realise how simple this is even in metabolism field. But 99%+ of Nitric Oxide molecules gets the N from aspartate.

 

I just realised that asparagine is directly related to N-Linked Glycosylation (I will inform Wenzhong Xiao and his team about this). N-Linked glycosylation is one of the first targets identified by machine learning. If ER Stress is indeed a problem in ME/CFS patients, disruption of N-Linked glycosylation could be the cause of it.

Entry of Wikipedia for Asparagine :



Blog post on N-Linked Glycosylation (October 2017)

http://algogenomics.blogspot.com/2017/10/latest-network-analysis-results.html


As always, I communicated these targets and the potential use of N-Acetyl Glucosamine (NAG) to several ME/CFS researchers in 2017. Interestingly, NAG may be helpful for some patients but caution is advised :

 

The fact that this is a preprint, data taken from small cohorts, and other potential methodological issues aside - this paper caught my eye because I've noted amino acid metabolism alterations as suggested findings in a few different studies now...

My urine urea output is about 50 % of the lower end of normal (according to 24 hour urine tests), for no explained reason. It may not be related, but findings like this catch my eye as I do ponder whether this could be related to some inefficiency of nitrogen metabolism, and whether this could be related to my ME symptoms. I will be interested to see whether this avenue is supported by further research.