The "Biology-First" Hypothesis: Functional disorders may begin and end with biology-A scoping review (2018)

hixxy · Jun 30, 2018

Neurogastroenterol Motil. 2018 Jun 28:e13394. doi: 10.1111/nmo.13394. [Epub ahead of print]

The "Biology-First" Hypothesis: Functional disorders may begin and end with biology-A scoping review.

Enck P, Mazurak N.

Abstract
While it is generally accepted that gastrointestinal infections can cause functional disturbances in the upper and lower gastrointestinal tract-known as postinfectious irritable bowel syndrome (PI-IBS) and functional dyspepsia (PI-FD)-it has still not been widely recognized that such an infection can also initiate functional non-intestinal diseases, and that non-intestinal infections can provoke both intestinal and non-intestinal functional disturbances. We conducted a scoping review of the respective literature and-on the basis of these data-hypothesize that medically unexplained functional symptoms and syndromes following an infection may have a biological (genetic, endocrine, microbiological) origin, and that psychological and social factors, which may contribute to the disease "phenotype," are secondary to this biological cause. If this holds true, then the search for psychological and social theories and factors to explain why one patient develops a chronic functional disorder while another does not is-at least for postinfectious states-misleading and detracts from exploring and identifying the true origins of these essentially biological disorders. The biopsychosocial model may, as the term implies, always begin with biology, also for functional (somatoform) disorders.

KEYWORDS:
biopsychosocial model; chronic fatigue syndrome; functional dyspepsia; irritable bowel syndrome; postinfectious; somatoform disorders
Click to expand...

https://www.ncbi.nlm.nih.gov/pubmed/29956418
http://sci-hub.tw/https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13394

Trish · Jun 30, 2018

I like the last sentence of the Summary at the end:
''In general, we believe that a stronger focus on the underlying biology and genetic processes of somatoform disorders will lead to progress in our comprehension of these diseases.''

Subtropical Island · Jul 5, 2018

hixxy said: ↑

https://www.ncbi.nlm.nih.gov/pubmed/29956418
http://sci-hub.tw/https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13394
Click to expand...

Want to read/hear more (can see just a paragraph more than the abstract without a sub).

Log in or Sign up

The "Biology-First" Hypothesis: Functional disorders may begin and end with biology-A scoping review (2018)

hixxy Senior Member (Voting Rights)

Trish Moderator Staff Member

Subtropical Island Senior Member (Voting Rights)

Share This Page

Log in or Sign up

The "Biology-First" Hypothesis: Functional disorders may begin and end with biology-A scoping review (2018)

hixxy Senior Member (Voting Rights)

Trish Moderator Staff Member

Subtropical Island Senior Member (Voting Rights)

Share This Page

Useful Searches