The bone marrow NK-cell profile predicts MRD negativity in patients with multiple myeloma treated with daratumumab-based therapy, Korst et al. 2025

[ryanc97]

Lol—if only it was $3000!

Darzalex faspro (1800 mg subcutaneous) in the United States is close to $11,000 for one injection. Obviously insurance won’t pay for it.

Oh wow that's ridiculous. Well my 3k quote came from my trusty Indiamart vendor whom I buy my antivirals and other drugs from.

 

[ryanc97]

Hi Ryan, and welcome! I’m glad you don’t have PEM, and here’s to hoping the fatigue and sleep issues eventually resolve. It’s enough of a challenge on its own.

Correlation doesn’t imply causation, so we don’t really know what the NK measurements mean in terms of response to Dara. I’m not even sure we have a rationale for why higher NK cells would make a difference.

The phase 2 of Dara for ME/CFS by Fluge and Mella might tell us more. They are using >125 as an inclusion criteria.

Watch the video of Oystein presenting at International ME CFS Conference 2025 -

ADCC is the mechanism by which NK cells attack the CD38 LLPCs which are theorized to produce the AABs.

 

[ryanc97]

By the way, I can see the link between EBV and Dara (there is strong link there) but not CMV/HHV6. Because EBV activates in LLPCs which Dara targets. But for CMV, HHV6, less so.

 

[ryanc97]

Similarly:

NK Cell Phenotype Is Associated With Response and Resistance to Daratumumab in Relapsed/Refractory Multiple Myeloma (2023, HemaSphere)

This is very encouraging. Maybe a pre-treatment is to jack up the NK cell counts as high as possible, either with transfers or supplements or herbs or whatever. Then hit it with the Dara