Trial Report The effectiveness of [tDCS] on brain fog in patients with long COVID-19: a study based on quantitative electroencephalography, 2025, Saeidmanesh et al

The effectiveness of transcranial direct current stimulation on brain fog in patients with long COVID-19: a study based on quantitative electroencephalography

Mohsen Saeidmanesh, Raziyeh Baniasadi, Mahdiyeh Azizi, Mahjoubeh Pourebrahimi

[Language of full text: Persian]

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Abstract
The present study was conducted to determine the effectiveness of transcranial direct current stimulation (tDCS) on brain fog in patients with long COVID-19. The present research method was semi-experimental with a pre-test-post-test design with a control group.

The statistical population of the study was made up of all patients suffering from brain fog caused by prolonged long COVID-19 referring to psychiatry and psychology clinics in Kerman in 2023. Among them, 30 patients (19 women and 11 men) were selected purposefully and randomly assigned to two experimental and control groups (15 people in each group).

In the experimental group, the subjects were treated with tDCS for 15 sessions (3 sessions per week, and each session was 40 minutes), and the control group received sham tDCS.

To investigate the brain waves involved in the subjects' brain fog was recorded quantitative electroencephalography (QEEG) from 19 locations of their brains before and after the treatment and the data were analyzed using dependent t-test and one-way analysis of covariance in SPSS-26 statistical software.

The results obtained from the study of brain wave changes showed that tDCS reduced delta and theta waves in the anterior (Fz, Fp1, Fp2, F3, and F4) and midbrain (Cz, C3 and C4) regions and improved brain fog at a mean level (p<0.05)

These results emphasize the effectiveness of tDCS to reduce the hyperactivity of slow waves in the anterior and central regions of the brain and to improve the brain fog of corona patients.

Link | PDF (Rooyesh-e-Ravanshenasi Journal) [Open Access]

 

Not enough of a study to get me excited, but it would be nice if they did find something useful.