Mij
Senior Member (Voting Rights)
Conclusion
In patients with ME/CFS, various studies have yielded inconclusive results regarding changes in the gastrointestinal processes where microbiota is involved. Whether these divergent findings are due to different molecular phenotypes of patients with ME/CFS remains speculative. Presently, dysbiosis in ME/CFS is to be understood as an association; causality is not proven from a critical perspective. Nevertheless, the growing comprehension of the interactions between the microbiome and the host presents an intriguing pathophysiological concept, forming the foundation for rational future therapeutic approaches. A randomized controlled study involving well-defined ME/CFS patients, encompassing post-exertional malaise (PEM), and employing repeated and long-term faecal microbiota transplantation (FMT), appears to be the most promising approach to establish causality. Such understanding of interactions will lead to concepts that help overcome therapeutic nihilism.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1352744/full
In patients with ME/CFS, various studies have yielded inconclusive results regarding changes in the gastrointestinal processes where microbiota is involved. Whether these divergent findings are due to different molecular phenotypes of patients with ME/CFS remains speculative. Presently, dysbiosis in ME/CFS is to be understood as an association; causality is not proven from a critical perspective. Nevertheless, the growing comprehension of the interactions between the microbiome and the host presents an intriguing pathophysiological concept, forming the foundation for rational future therapeutic approaches. A randomized controlled study involving well-defined ME/CFS patients, encompassing post-exertional malaise (PEM), and employing repeated and long-term faecal microbiota transplantation (FMT), appears to be the most promising approach to establish causality. Such understanding of interactions will lead to concepts that help overcome therapeutic nihilism.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1352744/full