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Open The ME-SH (ME in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in (ME/CFS) - a case control study 2021 Bragee

Discussion in 'Recruitment into current ME/CFS research studies' started by John Mac, Mar 4, 2021.

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  1. John Mac

    John Mac Senior Member (Voting Rights)

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    The ME-SH (Myalgic Encephalomyelitis in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome(ME/CFS) - a Case-control Study

    Not yet recruiting

    https://www.medifind.com/conditions/chronic-fatigue-syndrome/1135/clinical-trial/224113596
     
    John Mac, Mar 4, 2021
    #1
    Grigor, cfsandmore, Kitty and 2 others like this.
  2. Trish

    Trish Moderator Staff Member

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    100 people, ME/CFS and controls to be recruited starting next month. The end date is 5 years away, so that's 10 patients and 10 controls per year.

    If it's just done at one clinic that is now well known among pwME as focusing on neck/spinal problems, how will they be able to tell if it's a self selecting sample of pwME who have neurogical signs that might suggest neck obstruction, so get a skewed sample?

    I understand the aim is to determine prevalence of neck obstructions in people with ME/CFS, so that should be done, as any epidemiological study, with a representative sample selected from a population with ME/CFS of all severities.

    @Bjorn Bragee, can you help me understand this better, please? How will the sampling procedure be done?
     
    Trish, Mar 4, 2021
    #2
    Leila, Anna H, Sean and 12 others like this.
  3. mango

    mango Senior Member (Voting Rights)

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    mango, Mar 4, 2021
    #3
    Anna H, Helene and Andy like this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    The site says that recruitment will be based on non-probability sampling. That seems to mean that it will not be a random or representative sample. The net says: nonprobability samples cannot depend upon the rationale of probability theory

    That seems to mean that no conclusions can be drawn about the probability that the findings are representative of ME/CFS. In other words, it seems, they are not likely to tell us much?
     
    Jonathan Edwards, Mar 4, 2021
    #4
    Possibly James May, Leila, Anna H and 10 others like this.
  5. Trish

    Trish Moderator Staff Member

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    Trish, Mar 9, 2021
    #5
    mango and Leila like this.
  6. mango

    mango Senior Member (Voting Rights)

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    mango, Mar 9, 2021
    #6
    Andy, Midnattsol, NelliePledge and 3 others like this.

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