wastwater
Senior Member (Voting Rights)
https://www.frontiersin.org/articles/10.3389/fcvm.2021.681948/full
The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
Abstract
COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
quote
The first evidence that demonstrated Notch pathway-viral interactions was reported for the Epstein-Barr virus
I have a PITX2 notch3 (cadasil) interaction
The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
Abstract
COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
quote
The first evidence that demonstrated Notch pathway-viral interactions was reported for the Epstein-Barr virus
I have a PITX2 notch3 (cadasil) interaction
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