The risk of Long Covid developing from Covid-19 re-infections

Hutan

Moderator
Staff member
I'm wanting a good reference about the risk of Long Covid in subsequent infections. I couldn't find one immediately although I think we have seen a couple of papers on that topic.

If I find them, I'll post them here. But if you put your finger on them immediately, please do let me know.

Of course, the possibility of people developing an ME/CFS-type illness after subsequent infections is pretty consequential. It means that it's not just a relatively small number of susceptible people who will come down with an ME/CFS-type illness and everyone else will be fine. Instead, perhaps there will be an increasing proportion of the population that have the illness.

It also perhaps tells us something about the risk factors for developing an ME/CFS-type illness. Perhaps genes are not everything; perhaps environmental factors and chance are important.
 
Quickly, I have —

Acute and postacute sequelae associated with SARS-CoV-2 reinfection (2022, Nature Medicine)

The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase.

Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome (2023, International Journal of Molecular Sciences)

SARS-CoV-2 reinfection an OR of 2.211 (95% CI: 1.343–3.265; p = 0.014)

“The burden of post-acute COVID-19 symptoms in a multinational network cohort analysis” (2023, Nature Communications)

Persistent symptoms were more common after reinfection than following a first infection.

Risk of New-Onset Long COVID Following Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2: A Community-Based Cohort Study (2023, Open Forum Infectious Diseases)

The risk of new-onset long COVID after a second SARS-CoV-2 infection is lower than that after a first infection for persons aged ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset long COVID after a second infection, with around 1 in 40 of those aged ≥16 years and 1 in 165 of those <16 years reporting long COVID after a second infection.
 
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