Tropoflavin for brain fog

[Jaybee00]

Some people are reporting improvements in brain fog with this supplement. It’s available on Amazon as dihydroxyflavone.

https://en.wikipedia.org/wiki/Tropoflavin

Here is a paper

https://pmc.ncbi.nlm.nih.gov/articles/PMC9881092/

 

[Jaybee00]

Here is a prodrug of the above compound called R13–don’t know if there is any human data.

https://en.wikipedia.org/wiki/R13_(drug)

https://www.pnas.org/doi/10.1073/pnas.1718683115

 

[Hutan]

Tropoflavin, also known as 7,8-dihydroxyflavone (DHF), is a naturally occurringflavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves

Godmania is a tropical tree in the Bignoniaceae family. Tridax procumbens is a daisy (Asteraceae). That made me think that this 7,8-dihydroxyflavone is probably found in a lot of plants, because that's two different families, and lots of daisies are pretty similar to each other. And yes, I found a reference saying that the molecule is found in lots of plants including cherries, soy beans, green tea and apples. For what it is worth, another daisy, Chrysanthemum is also a BDNF agonist.

Perhaps there is a particular concentration in the named plants, and perhaps the molecule is concentrated in commercially available supplements, but it would be worth checking that out. There may be an element of hype going on.

Wikipedia's reference to 'primula tree leaves' is very odd, as, as far as I know primulas don't grow as trees. Primulas are in the Primulaceae family. I couldn't find any mention of some other sort of plant commonly called 'Primula Tree'. So, I think Wikipedia has a mistake there.

 

[Hutan]

Ha!
https://pmc.ncbi.nlm.nih.gov/articles/PMC10051830/
Some Nanocarrier’s Properties and Chemical Interaction Mechanisms with Flavones

Flavones such as tropoflavin, baicalein, luteolin, myricetin, apigenin, and chrysin (Figure 1) are studied mainly for their properties as pharmacological agents. 7,8-Dihydroxyflavone (tropoflavin 1) is a flavone found in species such as Godmania aesculifolia, Tridax procumbens, Primula farinosa L., and Chrysanthemum morifolium [33]. As a neuroprotective agent, the presence of 7,8-OH groups in its structure makes it a chemical agent that emulates the biochemical and physiological action of brain-derived neutrophic factor (BDNF) and serves as a selective agonist of the tropomyosin-related kinase B receptor (TrkB) [34,35]. The anticancer activity of tropoflavin has been demonstrated by Liu et al. (2020) [33], as an inhibitor of human ornithine decarboxylase (ODC), in in vitro studies. Similarly, it has been shown that tropoflavin had anti-enterovirus (EV71) activity at a concentration of 50 Μm. It inhibits 40% of viral IRES-internal ribosome entry site (IRES) activity by interfering with virus replication [36,37].

That reference suggests that Chrysanthemum is also a source of tropoflavin. And that primula species certainly isn't a tree - it's bird's eye primula.

Looks like the story got a bit mangled along the way.

 

[Creekside]

There may be an element of hype going on.

When isn't there?